#4mmc

I did 2 time synthesisise of 4 mmc 100 gram 2b4m in dcm and acidification with HCl i got 15 gram yield both time now i want to try bb gate video tutorial of 4mmc in NMP my question is what is the difference between Hbr and HCl for acidification and what are the benefits of Hbr and NMP solvent...

In my first synthesis of 4 MMC i followed genral procedure of 100 gram of bromoketone 200 ml 40 % methylamine and 300ml dcm 2hour 40 c temp posted on thread And crystallization in 50/50 ipa water solution I got 14 gram yield in first precipitation then remaining mother liquor and washing with...