Amphetamine from BMK (P2P). Please help

[Pemfloid]

Hi guys,

I got tired of looking info in multiple topics, answers, analyzing "Synthesis" books and not finding the best reasonable answer.

I do have access to P2P, but I am not ultra advanced chemist. I am looking for the best method to make reasonable maximum yield of amphetamine with relative not too much complicated procedure. Some theory says up to 1.4kg from 1L BMK. Other sources - usually less than 1kg.

"Amphetamine can be obtained in a 30% yield in a one-step synthesis by refluxing phenylacetone in ethanol with ammonia, aluminium grit, and a small quantity of mercuric chloride." 30% is too little as I have 10l of BMK only and would like to make as maximum as possible.

Can someone guide me? Sorry in advance if I missed a good answer in this forum somewhere.

Thanks.

 

[btcboss2022]

http://bbzzzsvqcrqtki6umym6itiixfhni37ybtt7mkbjyxn2pgllzxf2qgyd.onion/index.php?threads/amphetamine-from-p2p-phenyl-2-propanone.1378/

 

[btcboss2022]

Other way is make free amphetamine base from P2P+Formamide+Acid formic later HCL and make the amphetamine sulfate from the free base.

 

[Pemfloid]

SWIM is looking something higher than 30% yield. 3kg out of 10l P2P and

Reagents:​

• 40 g, 0.3 mole Phenylacetone (P2P) [CAS: 103-79-7];
• 200 mL Ethanol (EtOH) 96-98 %
• 200 mL 25 % Ammonia alc. (NH4OH);
• 40 g, 1.5 moles Al-grit;
• 0.3 g,1 mmol Mercury chloride (2) (HgCl2);
• ~200 mL Distilled water;
• 120 g Potassium hydroxide (KOH);
• ~450 mL Diethyl ether (Et2O);
• ~ 200 mL Hydrochloric acid 20 % (HCl) aq. solution;
• ~ 200 g Sodium sulfate (Na2SO4);
• ~30 mL Sulfuric acid conc. 98%.

 

[Pemfloid]

Is SWIM right saying that with Leuckart synthesis gives around 90-100% yield of P2P? Again, different sources states different numbers.

 

[WillD]

Different calculation methods. Leuckart is the most affordable route for large-scale production

 

[btcboss2022]

Different routes mate.