My understanding that precious metal catalysts seem to be the most atom efficient but often require pressure and hydrogen gas, which I believe limits scalability and reaction vessel size.
The leuckart is simple, easy, and cheap, but gives poor yields and seems to not be very atom efficient, but that's my thinking not based on math.
Mercury amalgam seems like it runs pretty hot at scale, and the toxic mercury is an issue.
It seems large-scale transfer hydrogenation with precious metal catalysts are the way to go, as I don't think this requires pressure. However. I can't find any examples of this being used on things like p2p, mdp2p, etc, and this leads me to think it must have its own issues for these substrates.
What do you guys think?
The leuckart is simple, easy, and cheap, but gives poor yields and seems to not be very atom efficient, but that's my thinking not based on math.
Mercury amalgam seems like it runs pretty hot at scale, and the toxic mercury is an issue.
It seems large-scale transfer hydrogenation with precious metal catalysts are the way to go, as I don't think this requires pressure. However. I can't find any examples of this being used on things like p2p, mdp2p, etc, and this leads me to think it must have its own issues for these substrates.
What do you guys think?