UR-144 synthesis from TMCP-indole (large scale). Complete video tutorial.

WillD

Expert
Joined
Jul 19, 2021
Messages
783
Reaction score
1,073
Points
93
UR-144 cannabinoid synthesis is represented in this topic.

Laboratory requirements:
The working place (a tabletop for laboratory syntheses and manipulations) must be supplied with exhaust ventilation and fresh air inflow. laboratory have to be equipped with multi-tiered racks for product drying. They have to be also supplied with good air ventilation. It is also worth to take care about weighing and packaging place. The place should has enough space, be convenient and be located under exhaust ventilation (preferably). Laboratory floors are recommended to be covered with a polyethylene film during synthesis procedures by reason that cannabinoid dust abundance cannot be avoided. Subsequently, the laboratory space will be more convenient to clean up by collecting polyethylene film.
Racks

Reagents:
2. Sodium hydroxide (NaOH);
3. Tetra-n-butylammonium bromide (TBAB) CAS 1643-19-2;
4. 1-Bromopentane (1-BP) CAS 110-53-2;
5. Distilled water (H2O);

Equipment and glassware:
1. Laboratory scale (0.1-200 g is suitable);
2. Flat-bottom flasks 10 l;
3. Funnel for bulk materials (with wide bottom);
4. Scoops for flour;
5. Beakers 1-2 l;
6. Electric burner;
7. Overhead stirrer (optional);
8. Silicone baking molds;
9. Syringes;
10. Blender;
11. Large bowl or bucket;

Individual protection:
Mask

1. Long sleeve chemical coat;
2. Respirator mask (or respirator + goggles);
3. Latex gloves;
4. Fabric gloves or a piece of thick fabric;

Addition:
1. TMCP-indol 2000 g is weighted and put into 10 l flask through a funnel for bulk materials;
2. Sodium hydroxide (NaOH) 1300 g is weighted and put into same flask;
3. TBAB 800 g is also weighted and put into same 10 l flask;
4. 1-Bromopentane 1500 g is poured into the flask;
5. Fresh water 3000 ml is poured there (better to use distilled water);
L5cwB8tbNY

Reaction:

The reaction mixture is stirred after reagents addition until NaOH is dissolved completely and two layers are formed. You can use cotton gloves under latex one to avoid burns, which can happen because NaOH dissolving is conducted with heat releasing. Also, it is recommended to use retort clamp apparatus.
Ur144rea1

As soon as two layers are divided and the all sodium hydroxide are dissolved, the flask is put onto the heating plate and the heating is turned on to the maximum power. Top stirrer is installed and turned on. In case you don't have a top stirrer, you have to use heat resistant gloves to avoid burns. The reaction mixture have to be stirred well in order to mix layers (be homogenized).
Ur144rea2

Top stirrer have to work during whole reaction procedure. In case you don't have top stirrer, reaction flask is shakes vigorously during whole reaction procedure. The simmer of reaction mixture is supplied until the mixture is become milky and without separated layers (homogeneous). It takes 15-30 min usually.
Ur144rea3

Next, heating plate is removed and reaction mixture is left for layer separation. Top layer is needed. Product can crystalize directly in the reaction flask, which makes it difficult to extract. According this fact, you have to do separation procedure quickly.
Ur144rea4

Top layer is moved into a beaker or directly into silicone molds (do not forget about the temperature, use thick gloves or towels). Top layer (oil) can be collected by a syringe. When the layer is become very thin, mixture can be poured into a measuring cylinder for much convenient handling.
Ur144rea5

Silicone molds with an oil layer are left for 24 hours to solidification. Silicone molds are used for more convenient handling because oil in these molds are solidified and taken their form.
Ur144rea6

Crystallized product is taken out and crushed. Than, UR-144 is placed onto trays, dried in well ventilated dry warm room. Usually, it takes 2 days. Also, you can use vacuum desiccator to dry it much faster. The yield is 3000 g.
Ur144rea7


This reaction procedure can be used for other JWH row cannabinoids.
 
Last edited by a moderator:

HIGGS BOSSON

Expert
Joined
Jul 5, 2021
Messages
557
Solutions
1
Reaction score
753
Points
93
Reagents used in video:
  • 1.50 g 2,2,2,3,3-Tetramethylcyclopropyl(1H-indol-3-yl)methanone (TMCP-indole; CAS 895152-66-6);
  • 2.32 g Sodium hydroxide (NaOH);
  • 3.10 g Tetra-n-butylammonium bromide (TBAB, CAS 1643-19-2);
  • 4.46 g 1-Bromopentane (amyl bromide; CAS 110-53-2);
  • Distilled water;

Equipment and glassware:
  • Flat bottom flask 2 L;
  • Retort stand and clamp for securing apparatus;
  • Magnetic stirrer with heating plate;
  • Reflux condenser;
  • Funnel;
  • Syringe or Pasteur pipette;
  • Beakers (600 mL x3, 100 mL x2);
  • Vacuum source;
  • Laboratory scale (0.1-200 g is suitable);
  • Measuring cylinder 250 mL;
  • Glass rod and spatula;
  • Separatory funnel 1 L (optional);
  • Buchner flask and funnel;
  • Filter paper;

Video Description:
0:05-1:12 - Alkali solution preparation;
1:13-1:42 - TMCP-indole addition into reaction mixture;
1:43-2:08 - TBAB addition into reaction mixture;
2:09-2:32 - 1-Bromopentane addition into reaction mixture (Rm);
2:33-3:50 - Rm is stirred and heated with reflux;
3:53-4:20 - Water is added at room temperature to clean the product from impurities;
4:20-5:10 - Top layer, which is contained UR-144, is decanted. Then, the bottom layer is extracted with benzene or ether to increase the yield. Solvent from this stage have to be distilled off for further product purification. Following purification steps can be skipped and top layer can be used for smoking mixtures producing in according with theory yield.
5:11-5:55 - Crystallization of dirty UR-144.
5:56-7:10 - UR-144 recrystallization from isopropyl alcohol (IPA) for product purification.
7:15-8:00 - Crystallized and cooled alcohol solution of UR-144 is filtred on Buchner funnel and flask. Filtered crystalline product is washed on Buchner funnel with a pure cold IPA. Keep in mind that product losses are possible in case of poor crystallization and insufficient cooling.

Same procedures are for following substances syntheses:
JWH-018 from 3-(1-Naphthoyl)indole and 1-Bromopentane,
AM-2201 from 3-(1-Naphthoyl)indole and 1-Bromo-5-fluoropentane,
JWH-122 from 4-Methyl-1-naphthyl-indole and 1-Bromopentane.
And many different synthetic cannabinoids. 1-Pentyl-1H-indole chemical structure is one of the main affect key factor on cannabinoid receptors (CB1 and CB2).
 
Last edited by a moderator:

joejoe354354

Don't buy from me
Resident
Joined
Dec 27, 2023
Messages
5
Reaction score
1
Points
3
I would like to ask, after I get the final crystallized product, what should I add to make the product return to an oily state for smoking?
 

Gus

Don't buy from me
Resident
Joined
Nov 12, 2021
Messages
7
Reaction score
8
Points
3
this video isnt working , is there another way i can watch it ?
 

Gus

Don't buy from me
Resident
Joined
Nov 12, 2021
Messages
7
Reaction score
8
Points
3
nevermind, you just need to wait a long time to load ,
 

battman23

Don't buy from me
Resident
Language
🇬🇧
Joined
Dec 23, 2021
Messages
14
Reaction score
6
Points
3
Deals
4
hi do you have a reliable source for theses raw materials
 

HIGGS BOSSON

Expert
Joined
Jul 5, 2021
Messages
557
Solutions
1
Reaction score
753
Points
93
Unfortunately, we have no suppliers. You need to look in China or India for the main precursor, the rest of the reagents are easy to find.
 
Last edited by a moderator:

battman23

Don't buy from me
Resident
Language
🇬🇧
Joined
Dec 23, 2021
Messages
14
Reaction score
6
Points
3
Deals
4
what is the main precursor i will have difficulty finding and what reagents are easy to find
 

HIGGS BOSSON

Expert
Joined
Jul 5, 2021
Messages
557
Solutions
1
Reaction score
753
Points
93
2,2,2,3,3-tetramethylcyclopropyl(1H-indol-3-yl)methanone (TMCP-indole) - main precursor, when ordering it, the supplier will understand for what purposes the substance will be used, although it is legal
Sodium hydroxide - Alkali, easy to reach
Tetra-n-butylammonium bromide - catalyst, not as simple as alkali, but there should be no problems with ordering in chemical stores, does not cause suspicion
1-Bromopentane - is a second precursor, but it is easy to obtain.
 

battman23

Don't buy from me
Resident
Language
🇬🇧
Joined
Dec 23, 2021
Messages
14
Reaction score
6
Points
3
Deals
4
thank you bro
 

sirmtr

Don't buy from me
Resident
Joined
Jan 12, 2022
Messages
23
Reaction score
10
Points
8
the most beautiful community so far here, I'm glad for what you built here, who is the owner I propose to make donations, I will be the first to donate, leave a bitcoin address something
 

chazchaz

Don't buy from me
New Member
Joined
Mar 11, 2022
Messages
9
Reaction score
2
Points
3
Am glad i found this forum
 

Bobi

Don't buy from me
New Member
Joined
Mar 18, 2022
Messages
6
Reaction score
1
Points
1
It is possible to use something else instead 2,2,2,3,3-tetramethylcyclopropyl(1H-indol-3-yl)methanone (TMCP-indole)
 

HIGGS BOSSON

Expert
Joined
Jul 5, 2021
Messages
557
Solutions
1
Reaction score
753
Points
93
You can first get a pentyl-indole, and then hang on it 2,2,2,3,3-tetramethylcyclopropyl chloride.
Or to obtain TMCP-indole by synthesis from indole and 2,2,2,3,3-tetramethylcyclopropyl chloride.
In any case, to obtain the ur-144, you need three main components. The synthesis TMCP-indole is quite complex, and it is as convenient as possible to buy it ready-made.
 

Bobi

Don't buy from me
New Member
Joined
Mar 18, 2022
Messages
6
Reaction score
1
Points
1
After I have done all the steps shown in the video what material do I get
 

Bobi

Don't buy from me
New Member
Joined
Mar 18, 2022
Messages
6
Reaction score
1
Points
1
Is the final material in the video an active cannabinoid and can be made from synthetic cannabis
 

Bobi

Don't buy from me
New Member
Joined
Mar 18, 2022
Messages
6
Reaction score
1
Points
1
I'm just talking about the video
 

HIGGS BOSSON

Expert
Joined
Jul 5, 2021
Messages
557
Solutions
1
Reaction score
753
Points
93
You will get UR-144, an active synthetic cannabinoid with a very high-quality psychoactive effect
 

MrSung

Don't buy from me
Resident
Language
🇬🇧
Joined
Mar 23, 2022
Messages
61
Reaction score
18
Points
8
Can i use 1-H-Benzolpyrol,Indole-Food grade Kosher(C8H7N)instead of TCMP as main precursor following the above procedure and then obtain the same result?
 
Top