Hey guys, I have some morphine galcial acetic acid and H2SO4.
Can somesone zell me how to make 6-mam wirht it?
Can somesone zell me how to make 6-mam wirht it?
6-monoacethlmorphine
- Thread starter RegulierTier
- Start date
Acetic acid isn't acylating agent, you should produce anhydride from it first.
Why 6-MAM? you do not have enough acid for two groups to make Heroin?
Why 6-MAM? you do not have enough acid for two groups to make Heroin?
- By RegulierTier
It's not about the quantity of educts, more about the quality of my products.
I don't want to acetylate both, 3rd and 6th position. To acetylate only the 6th position you need glacial acetic acid.
Acetic anhydride ist strong enough to acetylate both and create diamorphine but the 6-mam is much stronger than heroin.
I don't want to acetylate both, 3rd and 6th position. To acetylate only the 6th position you need glacial acetic acid.
Acetic anhydride ist strong enough to acetylate both and create diamorphine but the 6-mam is much stronger than heroin.
6-monoacetylmorphine is 30 times stronger than diacetylmorphine...
I think it's the same synthesis but with glacial acetic acid instead of acetic anhydride...
I think it's the same synthesis but with glacial acetic acid instead of acetic anhydride...
@RegulierTier, 30% stronger, not 30 times.
Where did you get this info? Don't believe everything that you read on Wikipedia if there are no links to reliable sources.
Where did you get this info? Don't believe everything that you read on Wikipedia if there are no links to reliable sources.
- By RegulierTier
Nevertheless i think it's a good idea to make directly 6-mam if you have pharmaceutical morphine, instead of making diamorphine... 
It's more potent and glacial acetic acid is easier to get your hands on, 'cause it's not a controlled or banned substance like acetic anhydride in most countrys.
It's more potent and glacial acetic acid is easier to get your hands on, 'cause it's not a controlled or banned substance like acetic anhydride in most countrys.
From my understanding glacial a.a. produces tar and to get white asia product use acetic anhydride..sodium sulfate in with the mix and heat with a water condenser on top for few hours. Should be info in this site literature. The aspirin synthesis is same also 5 drops concentrated sulferic acid to catalyze and start the reaction.the sulfite absorbs the water not wanted in reaction tho also H20 is byproduct. The hive and blue light has more info.
Tar is produced by acetylating raw opium, hence the presence of other acetylated alkaloids like noscapine etc. Also there has been what seems to be mis info about 6 mam or 3 mam or whatever on the web or rather ambiguous, Glacial Acetic does not produce a stronger product than does pure Acetic Anhydride as Glacial has water in it and we all know water ruins reactions. So glacial can produce perhaps a complete synthesis of the lesser MAM but AA brings about a 50 / 50 or something of the lesser and stronger. Its nearly impossible to exclude all moisture from the morph or cloroform inputs etc let alone isolating the reaction to exclude air/moisture so you end up with on average 50/50 mix. I got hung up on the 6 - 3 thing for a while but glacial is not the route to a better product.
I don't know these ppls info on 6-mam but it's the incomplete reaction from a a. And u should not think it's 30x stronger when it's a incomplete product of reaction..so some research yet could u spare any more? DM?
- By RegulierTier
It is 30% stronger... Do some research yourself bro.
6-mam is one of three metabolites of heroin (diacetylmorphine).
In your body the acetyl groups were detached, one after another.
One of the products ist 6-mam and the other ist 3-mam. The 3-mam is inactive but the 6-mam is way stronger than morphine 'cause of its high lipophilicity.
10% of this will metabolized to Morphine-6-Glucuronide which ist active too and 55%-75% are metabolized to Morphin-3-Glucuronid which ist inactive...
So it makes sense to produce and consume 6-mam instead of diacetylmorphine.
The arguement "it's an incomplete reaction" doesn't make any sense... In this case it would be smarter to make this "incomplete" reaction...
6-mam is one of three metabolites of heroin (diacetylmorphine).
In your body the acetyl groups were detached, one after another.
One of the products ist 6-mam and the other ist 3-mam. The 3-mam is inactive but the 6-mam is way stronger than morphine 'cause of its high lipophilicity.
10% of this will metabolized to Morphine-6-Glucuronide which ist active too and 55%-75% are metabolized to Morphin-3-Glucuronid which ist inactive...
So it makes sense to produce and consume 6-mam instead of diacetylmorphine.
The arguement "it's an incomplete reaction" doesn't make any sense... In this case it would be smarter to make this "incomplete" reaction...