DMT Synthesis Guide

DMT Synthesis Guide

Reagents:

  • Indole (cas 120-72-9) 25.0 g, 211 mmol;
  • Diethyl ether 700 mL;
  • Oxalyl chloride (cas 79-37-8) 55.0 g, 433 mmol;
  • Dimethylamine 1.94 mol in diethyl ether 20% wt/vol solution;
  • Distilled water 1 l;
  • LAH 1 M solution in THF 800 mL, 800 mmol;
  • Sulfuric acid (H2SO4 100%) 21.3 mL, 400 mmol;
  • THF anhydrous ~400 mL;
  • Glauber's salt (Na2SO4[H2O]10) 90 g, 279 mmol;
  • Heptane 250 mL;

Equipment and glassware:

2-(1H-Indol-3-yl)-N,N-dimethyl-2-oxoacetamide

Indole (25.0 g, 211 mmol) was dissolved in 400 mL diethyl ether, maintained at 0 °C, in a 3 L round bottom flask equipped with an overhead stirrer and ice bath. A 0 °C solution of oxalyl chloride (55.0 g, 433 mmol) in 100 mL diethyl ether was prepared and added in a rapid stream over a 30 sec period to the stirred indole solution via a pressure-equalized addition funnel. During the addition, yellow crystalline 1H-indol-3-yl(oxo)acetyl chloride precipitated immediately. Stirring was continued for 30 min after the oxalyl chloride addition was complete. The yellow 1H-indol-3-yl(oxo)acetyl chloride was not isolated, but the ethereal suspension was used directly in the next step.

A 20% wt/vol solution of dimethylamine in diethyl ether, prepared at 0 °C, was added dropwise to the vigorously stirred ethereal suspension of the 1H-indol-3-yl(oxo)acetyl chloride until the pH reached 9-10 (9.2 molar equivalents of dimethylamine:starting indole were added), while maintaining the reaction at 0 °C with the ice bath. After the addition was complete, an ivory-colored slurry of the 2-(1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide was observed within the reaction flask. Stirring was continued for 60 min, then the flask contents were suction-filtered through a Whatman #2 filter paper using a Büchner funnel. The filter cake was washed with 200 mL fresh diethyl ether and suctioned dry. This product was washed twice as follows: the filter cake was slurried in 500 mL water, stirred for 5 min, vacuum filtered using a Büchner funnel, resuspended in 500 mL fresh water, stirred for 10 min, then suction filtered once again. This near-white filter cake of 2-(1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide was suctioned dry, then placed in a vacuum drying oven at 40 °C or in a vacuum desiccator and dried to a constant weight. Yield 30.6 g (141 mmol, 67% of theory).

N,N-dimethyltryptamine (DMT)

2-(1H-Indol-3-yl)-N,N-dimethyl-2-oxoacetamide was reduced to DMT using a solution of aluminum hydride (AlH3; alane) in tetrahydrofuran (THF). Alane was generated in situ from lithium aluminum hydride (LAH). A 5 L round bottom reaction flask was equipped with a temperature probe, ice bath, Friedrich condenser, pressure-equalized dropping funnel, and overhead stirrer. To generate AlH3 in situ, a 1M solution of LAH in dry THF (800 mL, 800 mmol) was charged to the reaction flask and stirred, until the solution reached a temperature of 2 °C. One hundred percent sulfuric acid (21.3 mL, 400 mmol), produced by treating 96% H2SO4 with oleum (24.7% SO3), was added to the cold LAH solution, dropwise with vigorous stirring to avoid charring, over a period of one hour. Hydrogen is evolved, and lithium sulfate precipitates to give a clear solution of AlH3 in THF. To this mixture, a solution of 2-(1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide (3, 19.2 g, 89 mmol) in 200 mL anhydrous THF was added rapidly with stirring, while maintaining the temperature in the range of 0-4 °C. After the addition was complete, the fluorescent yellow-green reaction was stirred for 30 min on ice, then the ice bath was removed and replaced with a heating mantle. The reaction was heated to reflux for 3 hr, then returned to the ice bath.

Glauber's salt (Na2SO4[H2O]10; 90 g, 279 mmol) was added in portions with vigorous stirring to quench the reaction, maintaining the temperature below 10 °C. The formed greyish-white solids were removed by filtration through Celite 545 using a Büchner funnel with Whatman #2 filter paper. The filter cake was washed twice with fresh THF, resuspending the filter cake for each wash to recover any entrained product. The transparent light yellow filtrate was concentrated by rotary evaporation to yield 23.0 g of a transparent orange-yellow oil. The oil was dissolved in 250 mL boiling heptane, then allowed to stand at 4 °C; free base N,N-dimethyltryptamine (cas 61-50-7) crystallized as pure white crystals. Yield 12.6 g (66.7 mmol, 75% of theory).

  1. O

    Psilocin from DMT

    Hello friends. I am interested in easy and cheap DMT to psilocin convertion. I read all of this informations and try this synthesis but didnt get the good results. I was using freebase DMT. https://hyperlab.info/inv/index.php?act=ST&f=17&t=28950 Did somebody try this method? Maybe there is...
  2. G.Patton

    Simple DMT Extraction

    This brief video represents DMT acid-base extraction of Mimosa Hostilis root bark powder. The method is very simple and can be performed on a kitchen. See more about DMT extraction in DMT Extraction From Plants thread. Source: Thanks @ziema420 for the link
  3. Simple DMT Extraction

    Simple DMT Extraction

    Dedicated thread: https://bbgate.com/threads/simple-dmt-extraction.11338 See more https://bbgate.com/threads/dmt-extraction-from-plants.727 Source: https://www.reddit.com/r/GifRecipes/comments/6jvpy9/how_to_make_dmt_xpost_rhowto
  4. Rabidreject

    DMT and other tryptamine synth questions….please help…

    Okay so I have two syntheses of n,n-DMT and a rough idea of a synth for DET also. I have a couple of questions that I really need answering. I am not going to list the steps or anything, just the general gist of what happens in them or how they differ and why that confuses me. I have done the...
  5. Rabidreject

    PLEASE HELP! Water bath and rotovap questions…

    Hey guys, I have a synth coming up (currently waiting for the main reagent) and the synth calls for both a water bath and rotovap. So to put my situation into perspective it’s important to say that I am learning chemistry as a hobby and I do not make things for people other than myself! Okay...
  6. I

    Any Canadians need gear??

    Toronto 
    Are there any Canadians on here having trouble getting their gear ?? If I get enough interest I will begin the process of getting my shop set up on this fourm for you maple heads. Looking forward to serving you guys in the future! Stay safe. Stay vigilante.
  7. 7

    who knows how to make dmt from PHALARIS GRASS

    Question 
    who knows how to make dmt from PHALARIS GRASS who knows how to make dmt from PHALARIS GRASS
  8. Que!

    Que un viaje de Dmt sin tomar Dmt,el pder de la Dmt.OjO Spoilers Por que sintetizar Trip mejor que afentas

    DMT 
    Que pena que no podamos interactuar con los mejicanos ni con lo de la india o pakistan Supera quien sabe Iguala es posible Acercar que duda cabe Pero creo que es la definicon mas fidedignas de lo que es un viaje,de verdad,sin joder mirar esa pipa tios mirar esa pipa Que hay ahi un litro de dmt...
  9. A

    looking for wholesale MHRB vendor or straight up DreaMTeam chemical

    Question Looking for a vendor 
    I know of the big sites like Eteabea.com, I. hunting for better wholesale prices
  10. H

    Tryptamine synthesis DMT

    Is anyone familiar with the synthesis steps of dmt? Can you help me see where I'm going wrong? Experiment 1: 1、tryptamine is dissolved in methanol. 2、add formaldehyde solution of 2 molar equivalent. 3、 add methanol solution of sodium cyanoborohydride. 4、 mix and stir, slowly add glacial...
  11. R

    dimethylamine from dimethylformamide

    I prefer Shulgin's DMT synthesis using oxalyl chloride above all. It's really convenient apart from actually getting dimethylamine, as it is controlled. This video shows how it can easily be made simply, cheaply and in freebase form through hydrolysis of the amide in DMF with NaOH. You just need...
  12. J

    about the effects of DMT

    Question 
    Hello world, i experienced LSD a while ago and was enjoying seeing how beautiful this world is and who i really am, explored so many things and became hobbies personally. and my roommate told me that DMT is the direct train to experience NDE (Near Death Experience) haha even said the god...
  13. 6tom

    Would this dmt synthesis work

    Question 
    this synthesis originally came from“Synthesis of DMT (and analogs) from Tryptamine by Rhodium” I extended it more with greater detail I am just asking if I got everything correct since I am not the smartest at chemistry but have performed multiple synths but not in psychedelics. 1.“Dissolve 15...
  14. Gauss

    Ways to mess up DMT extraction

    Question 
    I was just wandering what are the most common ways to cause irreversible damage to your cook in way that you can no longer extract DMT from rootbark
  15. BlueFairyDMT

    BlueFairyDMT a.k.a BlueFairy is back on the forums. Just shout out of Love

    Hello I am so glad that I was able to discover this forum Breaking Bad. When I returned to vending dmt again after a 3 year hiatus dread forums went down. Anyways..... Just wanted to shout out some love to everyone. BlueFairy
  16. Agilent1100DAD

    Synthesis of N,N dimethyltryptamine freebase via Fischer Indole (with photos of the process and a video)

    Hope ya'll enjoy! 1. A medium sized magnetic stir bar was inserted into a 500 mL RBG flask. 18 g of phenylhydrazine HCl was dissolved in 250 ml of deionized water in a 500 mL 3 neck 24/40 joint RBF, which is put onto a heating mantel that acts as a magnetic stirrer. Neck 1 had a rubber septum...
  17. A

    Anyone know of plants in Australia that contain DMT?

    I would like to know so I can start extracting it. I think Acacia Longifolia contains about 0.3-0.8% but Im not sure.
  18. S

    My Best Substituted Tryptamines List So Far.

    Substituted Tryptamines 4-PO-DMT (Psilocybin) 4-HO-DMT (Psilocin) 4-HO-MET (Metocin) 4-HO-DET (Ethocin) 4-HO-MiPT (Miprocin) 4-HO-DiPT (Iprocin) What can you say about this?
  19. Albert Hofmann

    DMT

    INTRODUCTION: N,N-Dimethyltryptamine, commonly known as DMT, is a powerful psychedelic and mostly known for its short duration of action, unlike LSD, DMT effects can last from 15 mintues to 3 hours depending on the way it's taking. DMT can be injected, inhaled, or ingested with "monoamine...
  20. G.Patton

    Australian ayahuasca recipe

    Introduction Ayahuasca, iowaska, ayawaska, and yage all means the same thing. It is a hallucinogenic brew that contains DMT that gives people enlightening experiences that changes lives for the better. People that have taken ayahuasca tea reported astonishing positive effects such as finding out...
Top