Leuckart amination help

[Topesz123]

Hi i need help with leuckart reaction. i tried this reaction with ammonium formate but i keep getting finish yield about 50%. i heard that if use formamide instad of ammonium formaye yield is better.Do you have any synthesis with formamide for big scale

 

[WillD]

It is necessary to describe your synthesis in more detail so that we can help. You can here, or in private messages.

 

[Jack]

Search up M. B. Tolmie Masters Thesis - Australian Federal Police, it is a pdf related to the leukart reaction.

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[WillD]

p2p is good? which color? U buy it or do in yourself?

 

[WillD]

This link has no relation to the topic

 

[WillD]

With the reaction with formamide you will get about the same yields

 

[Jack]

Here is the pdf.

 

[tibby328]

50% is the max yield you will get