3-CMC in a 100L reactor, what route is most efficient and/or easiest?

[bubbler]

Hi,

If i want to do 3-CMC in a 100L reactor with chilling/heating system, what synthesis is best for that scale? And do i need to choose between easy OR cheap reaction or is there a middle-way to get a bit of both?

What would the ratio of the chems be to run the reactor at max capacity in one batch?

Thanks

 

[bubbler]

Would be happy if the forum oldtimers gave me some input as well =) I did see that @William Dampier have given some pointers on cmc reactions, @G.Patton as well. I have also seen @The-Hive in some discussions. =) Hope to get the discussion going.

I have read the threads where 100g batches of 3-cmc are discussed but would now like to get some pointers to do it in a reactor as well in a more professional manner.

 

[G.Patton]

Hello, the best way from 3'-chloro-2-bromopropiophenone, direct substitution nucleophilic, similar as with 4-mmc. Have you get 3-cmc by small scale batch?

 

[bubbler]

When it comes to solvent i think i would prefer DCM due to easy access unless you say otherwise?

 

[The-Hive]

There’s loads off different methods it’s what suites you best and what chemicals you can get @Netflix does 100g batch with 300ml DCM shake and bake style or ethyl acetate instead off DCM shorter reaction time

 

[bubbler]

Thanks for the answer, lets get the discussion going =)

"There’s loads of different methods, it’s what suites you best" thats why i came here to try to figure out together what would suit me best in this batch scale so i would be super appreciative with some more ideas and input regarding this.. I think i will need to discuss or at least understand the up/downsides of the different reaction routes before i can decide what would be right for me.

So DCM compared to what takes longer time? I have seen a lot of information scattered regarding CMC so now i will try to get everything into this tread.

 

[The-Hive]

Follow @Netflix that’s the Easiest method. You can all so look into Questions and answers section where you will find a lot more information