any 3CMC synthesis method?

[tajira]

Hello! can somebody provide me 3-cmc synthesis method?

 

[Bazooka90]

I would like to know also about that

 

[Selassi]

Yes im very curious too... Help would be greatly appreciated ofcourse

 

[WillD]

What are your starting reagents?

 

[Selassi]

Chloropropiophenone, but its the same route as with methylpropiophenone right?

 

[Selassi]

2-bromo, 3-chloropropiophenone to be exact

 

[dark_side_of_chemistry]

Yes

 

[Bazooka90]

If i am right, we can use the same method like for 4mmc synthesis, replacing 2-Bromo-4-Methylpropiophenone with 2-bromo, 3-chloropropiophenone?

 

[dark_side_of_chemistry]

Exactly all bromoketones we do the same ... if we bromine a compound, then we carry out amincaje some amine. mostly using SN2 for this.

 

[Bazooka90]

How can i do this process?

 

[WillD]

You just need to recalculate the proportions a little, and some features of crystallization

 

[Bazooka90]

Can you please tell which portions must be recalculated and how?

 

[Selassi]

Ok ok... So cryssing is different, it will not fall out with HCl and tempreduction or how?

Couldnt find this post from SynthMaster which is quoted above

 

[WillD]

In general, the process is almost the same for all replaced compounds, do not worry about it. If you have reagents, write in private messages, I will help with synthesis in detail.

 

[Selassi]

Which features do we need to change for crysallization? Does cmc crystallize with the freezermethod used in mmc-variants?

 

[WillD]

necessarily

 

[rafael1985]

Somebody can help with 3 cmc synthesis after acidification is still oil

 

[G.Patton]

How did you do this? Can you describe your procedure?

 

[rafael1985]

Procedure was the same like with 4 mmc but I put I think too much 35% HCL is possible to rescue this only is

 

[G.Patton]

what pH did you reach?