- Language
- 🇺🇸
- Joined
- Jul 27, 2024
- Messages
- 21
- Reaction score
- 10
- Points
- 3
1. Mix 40 grams of phenylacetone, 20 grams of methylamine hydrochloride and 200 ml of methanol, add 1 gram of sodium hydroxide to neutralize to weak alkalinity, and react at 60 degrees for 2 hours to generate an imine intermediate.
2. Add 15 grams of sodium borohydride to the imine intermediate and react at room temperature for 6 hours to generate amphetamine.
3. Add 100 ml of water to the reaction solution, separate the organic layer, and repeat washing three times. After using 100 ml of water each time, add an appropriate amount of hydrochloric acid to neutralize to pH 5.
4. Evaporate all the solvent and water, stop heating when the temperature is above 100 degrees, and the crystals are still not precipitated after cooling. Have I missed any important steps?
2. Add 15 grams of sodium borohydride to the imine intermediate and react at room temperature for 6 hours to generate amphetamine.
3. Add 100 ml of water to the reaction solution, separate the organic layer, and repeat washing three times. After using 100 ml of water each time, add an appropriate amount of hydrochloric acid to neutralize to pH 5.
4. Evaporate all the solvent and water, stop heating when the temperature is above 100 degrees, and the crystals are still not precipitated after cooling. Have I missed any important steps?