How to make Methylamine solution?
- Thread starter Methylamine
- Start date
you need to mix with aqueous solution of NaOh, watch the video, the same way works with methylamine.
React methylamine hcl with naoh and you get methylamine gas then react gas with H2O and check volume
Preparation of the maximum pure 40% methylamine solution from methylamine hydrochloride can be carried out as follows:
Materials:
- Methylamine hydrochloride (about 160 g)
- Distilled water (about 240 ml)
- Glass flask with a volume of about 500 ml
- Magnetic stirrer
- Thermometer
- Unloading crane
- Glass pipette
Steps:
1. Prepare 240 ml of distilled water in a glass flask with a volume of about 500 ml.
2. Put methylamine hydrochloride in a flask of water.
3. Place the flask on the magnetic stirrer and start stirring.
4. Preheat the mixture to a temperature of 50-60°C, using a thermometer to control the temperature.
5. Continue heating and stirring until the methylamine hydrochloride is completely dissolved.
6. Bring the volume of the solution to 400 ml, adding distilled water, if necessary.
7. Cool the mixture to room temperature while continuing to stir.
8. Adjust the pH to a value of 10-11 using a 10% NaOH solution.
9. Check the concentration of methylamine in the solution using test strips or another method, and, if necessary, adjust the concentration by adding either water or methylamine hydrochloride.
10. Leave the mixture for a few hours or overnight so that all impurities settle to the bottom of the flask.
11. Filter the solution through a filter to remove any remaining impurities.
12. Ready-made methylamine 40% solution can be used in appropriate applications.
Please note that when using any chemicals, appropriate safety measures must be observed, including but not limited to: work in a well-ventilated area, use protective clothing and gloves.
Materials:
- Methylamine hydrochloride (about 160 g)
- Distilled water (about 240 ml)
- Glass flask with a volume of about 500 ml
- Magnetic stirrer
- Thermometer
- Unloading crane
- Glass pipette
Steps:
1. Prepare 240 ml of distilled water in a glass flask with a volume of about 500 ml.
2. Put methylamine hydrochloride in a flask of water.
3. Place the flask on the magnetic stirrer and start stirring.
4. Preheat the mixture to a temperature of 50-60°C, using a thermometer to control the temperature.
5. Continue heating and stirring until the methylamine hydrochloride is completely dissolved.
6. Bring the volume of the solution to 400 ml, adding distilled water, if necessary.
7. Cool the mixture to room temperature while continuing to stir.
8. Adjust the pH to a value of 10-11 using a 10% NaOH solution.
9. Check the concentration of methylamine in the solution using test strips or another method, and, if necessary, adjust the concentration by adding either water or methylamine hydrochloride.
10. Leave the mixture for a few hours or overnight so that all impurities settle to the bottom of the flask.
11. Filter the solution through a filter to remove any remaining impurities.
12. Ready-made methylamine 40% solution can be used in appropriate applications.
Please note that when using any chemicals, appropriate safety measures must be observed, including but not limited to: work in a well-ventilated area, use protective clothing and gloves.
In the lefetamine synthesis here at BB, one step had the synthesis of dimethylamine (DMA) by treating DMF (N,N-dimethylformamide) with NaOH. The generated DMA was transported via tubing to a flask of MeOH where it was quickly dissolved.
Here is that procedure, posted by Patton :
In a flat-bottomed flask (FBF) was placed 10 g dimethylformamide (DMF) and 40 grams of a 30% NaOH solution was added, upon which the solution turned a yellow colour. The FBF was closed with a rubber stopper fitted with a glass tube, plastic tubing attached led from this tube to another glass tube immersed in 90 ml methanol in another FBF. The FBF containing the DMF/NaOH mixture was placed on a hotplate and the temperature was gradually increased until gas generation started (only gentle heating was needed, around 50°C). All dimethylamine dissolved readily in the methanol and there was no odour discomfort arising from this. When gas evolution ceases, the yellow colour of the original mixture suddenly faded and became clear. At this point, the alkaline hydrolysis of DMF has finished, so beware of suck back that will occur if one is careless! After weighing the dimethylamine in methanol solution, it was observed that the weight had increased by 4.75 g (~77% yield or about 0.1 mole, ignoring the fact that the gas was not dried).
By extrapolation, this could be done with N-methylformamide, replacing the MeOH in the receiver for water, yielding an aqueous MeNH2 solution. For example, for a 30% MeNH2 solution, start with 70g DH2O in the receiving flask, and stop when the net weight in the receiving flask reaches 100g.
Here is that procedure, posted by Patton :
In a flat-bottomed flask (FBF) was placed 10 g dimethylformamide (DMF) and 40 grams of a 30% NaOH solution was added, upon which the solution turned a yellow colour. The FBF was closed with a rubber stopper fitted with a glass tube, plastic tubing attached led from this tube to another glass tube immersed in 90 ml methanol in another FBF. The FBF containing the DMF/NaOH mixture was placed on a hotplate and the temperature was gradually increased until gas generation started (only gentle heating was needed, around 50°C). All dimethylamine dissolved readily in the methanol and there was no odour discomfort arising from this. When gas evolution ceases, the yellow colour of the original mixture suddenly faded and became clear. At this point, the alkaline hydrolysis of DMF has finished, so beware of suck back that will occur if one is careless! After weighing the dimethylamine in methanol solution, it was observed that the weight had increased by 4.75 g (~77% yield or about 0.1 mole, ignoring the fact that the gas was not dried).
By extrapolation, this could be done with N-methylformamide, replacing the MeOH in the receiver for water, yielding an aqueous MeNH2 solution. For example, for a 30% MeNH2 solution, start with 70g DH2O in the receiving flask, and stop when the net weight in the receiving flask reaches 100g.