How to reduce phenylacetone with lithium aluminum hydride(LiAlH4)

[Aleffine]

Hi,
I saw in the forum that p2p was reduced with sodium borohydride and Al/Hg, but these two are not available in my country, except for lithium aluminum hydride. Is the process of reducing p2p with lithium aluminum hydride the same as sodium borohydride?

Thanks

 

[w2x3f5]

It would be logical to obtain an imine in anhydrous THF from p2p and methylamine, then drop this solution into a mixture of lithium aluminum hydride in anhydrous THF.

 

[Aleffine]

Thanks

 

[w2x3f5]

Please note that when an imine is formed from p2p and methylamine, water will be released; the water must be bound.

 

[btcboss2022]

Why does practically no one talk about the reduction of P2P in THF with ammonia(NH3) and LiAlH4 to obtain amphetamine?
Furthermore, surprisingly, I have found little information about it, but at first glance, it seems short enough and not excessively difficult to warrant some attention. Or am I missing something when analyzing it apart from the water issue?
4 P2P +4 NH3+LiAlh4 → 4 Amphetamine + Al(OH)3 + LiOH

 

[w2x3f5]

Sodium borohydride produces a large amount of dirt at the exit. I will assume that the secondary amine reacts more readily with p2p, plus the reduction reaction of p2p. I don’t see any advantages to using lithium aluminum hydride