New synthetic cannbinoid compunds out from nutmeg?

[Kj12]

hey bbgate community,

i am on research of nutmeg and his ingredients
i found 3 compounds that as a affintiy to the CB1 and CB2 receptors that are Malabaricone C , Licarin A, 5-Methoxylicarin A
my question is can make out from Nutmeg Synthetic cannabinoids?. the interessiting substance is Licarin A it has how the JWH-x
and Pinaca-x series a indazole structure.
i dont know about the potency from this 3 Substance but when they are not strong enough can make out of nutmeg strong cannbinoids derivates?

 

[WillD]

The structures of these substances really resemble some designer noids. For example, Vitamin E has some affinity for cannabinoid receptors.

"Nutmeg has been used both medicinally and recreationally for the treatment of anxiety and mood disorders. El-Alfy et al. [12] demonstrated that the administration of nutmeg extracts produces behavioural effects similar to Δ9 -THC, a known exogenous cannabinoid and the major psychoactive constituent of marijuana. Later investigation revealed that these extracts did not have direct CB1 or CB2 receptor binding affinity. [13] To determine the effect of nutmeg on the endocannabinoid system, indirect modulation was thus assessed. Using an assay-guided fractionation approach coupled to in vitro assays of FAAH and MAGL inhibition"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938946/pdf/jphp13174.pdf

Here we get an indirect effect, like some other types of noids (allosteric modulators for example). In any case, good structures for RC design ideas