Reduction of p2np via yeast

41Dxflatline

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Found this interesting paper on sigma:

https://www.sigmaaldrich.com/GB/en/tech-docs/paper/262155

ABSTRACT

Microbial reduction of 1-phenyl-2-nitro-1-propene (3) was carried out using 57 strains of yeast, 40 strains of aerobic and facultatively anaerobic bacteria and 40 strains of strictly anaerobic bacteria. Nine strains of yeast (Candida tropicalis, etc.,) had the ability to reduce (3) to 1-phenyl-2-nitropropane (1) (94.1%-60.3% yield). The ability of the aerobic and anaerobic bacteria was weaker than yeast (35.6%-14.0% and less than 5%, respectively). When 11 strains of strictly anaerobic bacteria (Clostridium innocuum etc.,) were used, a final reduced product like amphetamine (2) was detected, although the efficiency of reduction was very poor.
 

41Dxflatline

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And bacteria. Yields are low though
 

UWe9o12jkied91d

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There's also a bunch of chinese patents using baker's yeast and a japanese one that claims 70-90% yields, interestingly best yield are at 1:30h reaction time, 30* C
I will dig them up if I don;t forget
 
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