4mmc synthes in ethyl acetate

[The Villain]

Hi everyone.
Does anyone know, at what temperature and for how long the synthesis of 4mmc takes, using the ethyl acetate solvent ?

Is it the same as in toluen or benzen
3 hours and heat 60 degrees ?

 

[TheVacuumGuy]

video says:
- no heating
- 20 minutes reaction time
- color changes very visible

my experience is :
- keep at 40
- 30 minutes reaction time
- color changes are subtle, but at some point it will turn brown (when dark yellow, just wait more).

 

[PharmacopeiaLabs]

is this timeframe without using triethylamine?
Just 2b4m,methylamine and ethyl acetate?
as far as i understand, ethyl acetate makes the reaction much faster than DCM, correct me if am wrong.