Bromination of 4-methylpropiophenone with CuBr2 (large scale)

[WillD]

Reaction scheme:

Synthesis:
1. Added to the flask, 1000 g 4-methylpropiophenone.
2. Poured 6000 ml of acetonitrile or ethyl acetate, and start stirring.
3. While stirring, slowly add the copper(II) bromide 1800 g.
4. Put a reflux condenser on the flask.
5. Heated under reflux for 24 hours.
6. After this time, stop heating and stirring.
7. Distilling the solvent, if needed, to obtain dry bromoketone.
8. We leave away ethyl acetate, if we plan to react in it. Theoretical yield: 1400 g.

 

[beetlebb]

What is the obtain or actual yield on this synthesis?

 

[WillD]

Approximately 1 kg of finished substance

 

[beetlebb]

thanks

 

[Spindy122]

With ethyl acetate used, this is mostly complete in 1 hour. Complete in 2 hours.

 

[Morpheus77]

Can this method be used with valerophenone to get a-bromovalerophenone?