Question Cocaine analog

[kevin_smith_2]

Hello! We are looking for cheap and good analog of cocaine based tropane alkaloid .
Can you recommend us something else besides troparil?

 

[Osmosis Vanderwaal]

There's a site on the marketplace in China offering 4-flouro- cocaine HCl. Just knock that para- fluorine off there and you have genuine synth cocaine for $30/g. There's the win series, win 35,xxx is para -choro Troparil, it is the standard cocaine analogs are measured again for dat agonism. Good luck finding it. They have $30/kg samples of 2-methoxy-3-tropinone on Alibaba. Just needs a benzl benzoyl moiety and a methyl ester for cocaine and a ring substitution benzyl lands you at a mountain of cocaine analogs

 

[HerrHaber]

this sound's appealing and I have much interest in a protected form of anhydroecgonidine that is safe to send around and would yield the troparil analogs with a single reaction with organometallic reagent as an aryl donor.

 

[HerrHaber]

I would much appreciate a link to a trustworthy supplier of what you mentioned, if only you are kind enough, so please feel free to P.M. me if you avoid posting this in public. Cheers!

 

[Osmosis Vanderwaal]

I wouldn't dream of speculating on the reliability of Chinese chemicals manufacturers. If I was incredibly brave and in a position to do so, I would definitely order the samples from every one listed in Alibaba. If I paid for 10 samples and received 1, I would be ecstatic. They are in position to steal your money or mail you this precursor for $2- $180

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m.alibaba.com

 

[kitboy]

How could I add the benzoic acid to the molecule?

 

[waltershite]

hey made an account to ask, how would I knock off the para-flourine?

 

[Osmosis Vanderwaal]

The first method I thought was viable was zinc. I also saw a ring defluoration of a 4-substituted phenylamine using just NaOh. I assume you would protect the tropane, it it may be protected anyway by steric hinderance or the ethyl esters moity, which might take a hit but is easy to replace. As a 3rd idea, you could remove the hole benzoyl moiety and replace it with an unsubstituted benzoyl. I forget what molecules the paper para- reduced with just NaOh, but it was analogous to cocaine.

 

[UWe9o12jkied91d]

Haber said PhMgBr

 

[sadow]

@Frit Buchner Do you have more information on fluorococaine? what effects does it have? is it like cocaine or is it shit?

 

[UWe9o12jkied91d]

It might be neurotoxic, but I would expect it to work the same as far as potency
Edit: lookinh at the wiki page seems like I was right, about equipotent, more serotonin, toxicity unknown

 

[Osmosis Vanderwaal]

I did a fairly exhaustive search and found very little. I couldn't even find a reference to the 100x serotonin claim. If that was shown in a biopsy of a monkey brain, I would say that 4-f-c was an sri at 2mg and that's it. A strong dose of pharma cocaine is 2mg/kg , and I think 200 mg of fc would be serotonin syndrome out the ass. There's basically no experience reports for it ( 1 at Erowid, but if you read the author says 4-chloro-cocaine in the body of the report). But like I said knocking that off can be done.

 

[HerrHaber]

structure-activity relationship wise the F in the 4'th position should make the compound slightly more potent but the size of the atom is less likely to cause significant toxicity, as the mass of the halogen increases the toxicity potential can be put in discussion (for example 4-chloro-amphetamine is such a potent 5HT releaser that kills all serotonin neurons but the rigid analog of the 2-amino-indane lack's this
insane level of toxicity).

 

[UWe9o12jkied91d]

thanks,doc

 

[HerrHaber]

Over all I think it's pretty much meaningless to tire yourself and loose lots of material since the 4-fluorinated analog is likely to be more potent and if there is an increase in toxicity it may well be irrelevant (this is a personal oppinion that was not thoroughly researched befor posting this so please excuse me if I'm wrong for I know that I should read some papers before stating my oppinion).

 

[Osmosis Vanderwaal]

This document is in the library. It starts with arecoline hbr, which is the principle active constituent of betel nuts. In step 1 they use a grignards that is tough to make but product 1, racemic+- is equipotent to cocaine, so talk about easy!

http://bbzzzsvqcrqtki6umym6itiixfhni37ybtt7mkbjyxn2pgllzxf2qgyd.onion/resources/chemistry-and-pharmacology-of-the-piperidine-based-analogues-of-cocaine.114/

 

[sadow]

The α-PHiP what is it? is it similar to cocaine? I don't see much information about it. I want something that I can consume and have the same effect as cocaine but cheaper.
If someone can give me some information, I have to buy Viagra and where I buy it they sell this too
so i make the order

 

[Osmosis Vanderwaal]

It's a cathinone. It's actually way stronger than cocaine in the dopamine agonist department. Some of that stuff (a-pihp, a-php, a-pvp) makes people lose their shit and eat people's faces. A strong dose is 25mg it something, compared to 200mg for cocaine. I'd definitely try it

 

[sadow]

I'll buy 1 g to try it and I'll comment how it goes hahaha I hope I'm not too violent after taking it

 

[Osmosis Vanderwaal]

Start low! I realize This link is a-php, but it's going to be similar 40mg oral or 25:smoked will make you want to run and jump .vif it made me do that, it's fucking strong. I certainly don't do that smoking meth or crack

 

[vis]

APHP is APVP+... from pubs.acs.org;
"Increasing the length of the α-carbon side chain of 1-phenyl-2-(pyrrolidin-1-yl)ethan-1-one analogs from a methyl (α-PPP) to a propyl (α-PVP) group caused a steep increase in affinity at MR subtypes, and one extra carbon (α-PHP) further enhanced MR affinity"

 

[bblanco]

Try Dimethocaine

 

[Osmosis Vanderwaal]

I'd like to try some too! I believe I read it's 1/3 the potency of cocaine, but they are comparing it to pharmaceutical grade. If you consider the average purity of the end users product (50%) then it is 60%™as potent as cocaine. There's really not many I wouldn't try.

 

[bblanco]

Dimethocain (DMC, larocaine), a synthetic derivative of cocaine, is a widely distributed "legal high" consumed as a "new psychoactive substance" (NPS) without any safety testing, for example studies of metabolism. Therefore, the purpose of this work was to study its in-vivo and in-vitro metabolism by use of liquid chromatography-(high resolution) mass spectrometry (LC-HRMS). DMC was administered to male Wistar rats (20 mg kg(-1)) and their urine was extracted either by solid-phase extraction after enzymatic cleavage of conjugates or by use of protein precipitation (PP). The metabolites were separated and identified by LC-HRMS. The main phase I reactions were ester hydrolysis, deethylation, hydroxylation of the aromatic system, and a combination of these. The main phase II reaction was N-acetylation of the p-aminobenzoic acid part of the unchanged parent compound and of several phase I metabolites. The metabolites identified were then used for identification of DMC in rat urine after application of a common user's dose. By use of GC-MS and LC-MS
standard urine-screening approaches (SUSAs), DMC and its metabolites could be detected in the urine samples.
Dimethocain optional dosages
Dimethocain needed for leisure use is normally used for instance like cocaine, insufflated, it really is also easy to take it intravenous. It's not necessarily recommended to take the unusually high dosage amounts of dimethocain to obtain a cocaine like rush, that the amount can be excessive it can be considered a main problem for your cardiovascular system. Insufflated a normal the amount of dimethocain ranges from 100 close to 2 hundred mg, but newbees should start off with lesser levels, suggested are Fifty milligrams.





In case that used intravenous, than the medication dosage could be far lower, however buyers even so use up to A hundred milligrams to reach greater effects.

 

[bblanco]

If you want dan it, contact me

 

[kotkata]

Do you know any decent sources in the EU for DMC?