Purity of methamphetamine with a Refractometer

Joker_55555

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Hello, is it possible to measure the optical purity of methamphetamine with a Refractometer?
 

G.Patton

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It is quite hard by reason of these issues:
  • 1. lack of data
  • 2. unstable refraction index (depends on temperature of the sample)
 

Joker_55555

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Optical compounds have the same physical and chemical properties, the only difference is in the polarization of light. It does not appear to be measured with a refractometer.

All we need is a polarimeter.
 
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G.Patton

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In fact, you are partially mistaken. They can have different chemical reactivity (tartaric acid interaction with amphetamines is a bright example), different spin-spin interaction in molecule in a space (NMR analysis). About refraction - you are right, I was wrong.
 

Joker_55555

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When tartaric acid reacts with amphetamine, it is no longer a photoactive compound, but becomes a diastereomer. It is in the nature of diastereomers that their properties are different from each other, but before the reaction of racemic amphetamine, it does not show chemical and physical difference.

In nmr analysis, as far as I know, the isomers cannot be distinguished together, but they are mesomers. If you have an example, provide it.
 

G.Patton

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I don't have an example, read about Two-dimensional nuclear magnetic resonance spectroscopy if you are interested in.
I don't know what do you mean under photoactive compound.
I told about chemical differences. Different reactivity is also partially physical characteristic as spin-spin interaction of atomos in the molecule.

I don't see a reason to continue this thread.
 

Joker_55555

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I don't know what do you mean under photoactive compound.

photoactive: I don't mean racemic, it was typed wrong
 

Joker_55555

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I don't have an example, read about Two-dimensional nuclear magnetic resonance spectroscopy if you are interested in.

You need to give an example to prove your claim, as I mentioned before you cannot distinguish optical isomers with nmr, both isomers have the same spin. These two compounds differ only optically.
 

Joker_55555

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I don't see a reason to continue this thread.

Yes, I see no reason to continue the discussion, it is pointless. You should read organic chemistry carefully
 
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G.Patton

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Hey, that sounds pretty insulting. I don't have to prove anything to you, man. This forum environment involves friendly communication. No need to be so rude and toxic.
 

Joker_55555

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I'm sorry that you took my words like that and I'm even more sorry that you blocked me for a month.
 

Osmosis Vanderwaal

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So maybe this will clear it up. If you have a dextro substance it turns clockwise. A leavo turns counterclockwise. If you have a racemic mixture that is 50/50. You see no chirality because the net product is 0°. If you have a 60/40 mixture it rotates right but you have no idea how much a 60/40 mix would bend light, unless you just measured a pure isomer at your current temperature, barometric pressure ect
 

ACAB

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Yes you can, 100% has an Index of 1.503
 
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