4-mmc synthesis

I've tried this synthesis and gotten yields ranging from 30% 45%. Sharing in case it might be helful to others. Vice versa, other people might know changes to this synthesis for higher yields. Improvements are always welcome Needed: 100 g 2-bromo-4-methylpropiophenone 500 ml DCM 200 ml...

Reaction scheme: Reagents: 2-Bromo-4'-methylpropiophenone (cas 1451-82-7) - 5 kg; n-Methyl-2-pyrrolidone (NMP; cas 872-50-4) - 20 L; Methyl amine 40% aq. solution (cas 74-89-5) - 8 L; Benzene - 20 L; Acetone - 30 L; Hydrochloric acid con. aq. solution (HCl 36%) ~ 1.5 L; Distilled water - 20...

Reaction scheme: Reagents: 4'-Methylpropiophenone (cas 5337-93-9) 5 kg; Сooper(II) oxide (CuO) 2.7 kg; Isopropyl alcohol (IPA) 50 l; Iodine 6.5 kg; Equipment and glassware: 100 L Batch reactor, which is equipped with drip funnel, top stirrer, thermometer, temperature control system...

Reaction scheme: Reagents: 4′-Methylpropiophenone (cas 5337-93-9) 1000 g; Hydrobromic acid 48% aq. 1140 g or 765 ml; Hydrogen peroxide (H2O2) 35% 328 g or 290 ml; Sodium bicarbonate (NaHCO3); Distilled water; Equipment and glassware: Three necked round bottom flask 5 L; Retort stand and...

Reaction scheme: Reagents: 1. 4'-Methylpropiophenone (cas 5337-93-9) 1 kg; 2. Hydrobromic acid 48% 1300 ml; 3. Hydrogen peroxide 35% 750 ml; 4. Sodium/potassium hydroxide 25% (NaOH/KOH) aqueous solution; 5. Distilled water; 6. Ethyl acetate 6 l; 7. Methylamine 40% aq - 2 l; 8. Acetone - 8 l...