4mmc - question about non polar solvents

ifeelsorry

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Hello I've synthesised 4mmc like 4-5 time before, i was following this synthesis method

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So i was using benzene but I've heard it's very toxic, so what should i replace it with?
Which one give high yield?
I used to
Heat benzene at 40-50° for 3 hour will i newd to heat other solvent as well?

Also let me know how much quantity I will need to use of that solvent? I used to use 200 ml Benzene for 100g 2b4mp

And will i have to change anything in synthesis method that i was following?




 

PersonVPN

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You can use a lot of solvents for this! Benzene, xylene, DMSO, DMF, NPM, DXM, toluene, I even did it in Isopropyl alcohol once! But in some solvents, the reaction conditions change! The question is what you want to replace and for what purpose.
Remember, there is no harmless chemistry. There is harmful to health, Very harmful, and Just poison!
Therefore, always use personal protective equipment.
 
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