a-PVP without the ketone

[APVP-EU]

What if you removed the ketone/ether group from PVP,
has this been done and has this been tried before..??

 

[Osmosis Vanderwaal]

 

[Osmosis Vanderwaal]

A one pot Wolfe-Kishner reduction should do it. The W-K also makes bk- MDMA into MDMA. It removes a beta-ketone

 

[APVP-EU]

Interesting! Is there a name for "meth" with the NH2 group replaced with a Pyrrolidine? Should get a bit more potent then perhaps

 

[Osmosis Vanderwaal]

This doesn't have an N-methylate, and I opted for a racemic a-methyl. Technically I suppose this is the amphetamine analog. Tell me where you want the other methyl and I'll add it. This chemical in the picture is a precursor to SD573 carbonate, a pesticide.

 

[LabPsycho]

I someone reacts P2P, pyrrolidine, 85% formic acid and some Lewis-acid catalyst (to make the connection to P2P's carbonyl group), let's say AlCl3 for 12-16 hours.
Then if it produces the wanted imine first, what is the most OTC method to reduce the produced imine, if this kind of reaction even works?

 

[APVP-EU]

Im thinking it would be interesting to put another Nitrogen first to get somewhat close to both the N-Methylamine as well as the Pyrrolidine but at the same time kind of. Looks pretty neat as is thou

 

[reflame]

Nice, nice — looking good and smell “fishy” (haha!). If possible, why not try?

 

[William D.]

I think the original product is better.

 

[loadingST]

Xd this is not good at any means, short carbon chain with tertiary amine is absurd haha, bad idea i think.