Alpha-PVP synthesis (1-10kg scale). Complete video tutorial.

[keras]

Can I acidify in water solutiom not with acetone? And evaporate water afterwards like with 4mmc?

 

[G.Patton]

You can use less concentrated HCl aq solution.

 

[G.Patton]

You can read a-PVP crystallization topic.

 

[RegulierTier]

Can I use toluene instead of Ethyl acetate so I don't need to use a rotary?

 

[G.Patton]

Hello, you can don't use it with EA as well.

 

[G.Patton]

You are not obligated to use rotovap in any case. Try to carry out synthesis in a small scale at first.

 

[RegulierTier]

Hey, i've made everything like in the Video but after I added Aceton and hcl to the freebase, it seperated into two layers. I've just put it to the freezer without seperating the two layers from each other. Is that okay?

 

[lapgan1]

I always have the same situation as you if I don't evaporate ethyl acetate, only when I evaporate ethyl acetate does it precipitate.

 

[RegulierTier]

Ok what should I do now? Just heat a bit and wait until some evaporated?

 

[lapgan1]

Heat until the odor of ethyl acetate is gone. use acid hcl 36%

 

[Polka999]

even if lines split after finishing adding HCL you should be good to go. they will still crystalize inside fridge (at least for me they crystalized)

 

[G.Patton]

Hello, yes, it is okay.