Taking any drugs puts a strain on the human body and if there are "weak points" in the body at the physiological level, then drugs will show you this in the form of acquired health problems. It is necessary to actively help our body so that this does not happen. Chronic drug use is not good for the physiology of the body, but nevertheless - each of us found ourselves in a situation where the intake of substances can be uncontrolled. The mechanism of "depletion" of bodily and mental forces lies in changing the functions of the biochemical systems of the brain - dopamine, nor-epinephrine and serotonin.
Psycho-stimulants inhibit the re-uptake of dopamine and nor-epinephrine in neurons. The predominant influence of psycho-stimulants on the serotonin system is its inhibition, associated with blocking the re-uptake. They also reduce the concentration of serotonin and its metabolites in biological fluids. All this leads to a shift in emotional status - to an increase in mood, euphoria and stimulation of mental activity.
The classical structure of intensive mid-static chronic use, after which it will take a significant time to recover, is as follows - 2-3-4 days of use of the substance with an increase in a single dosage and multiplicity of administration, then there is a phase of "relaxation" for about 4 days, then either the use of the drug is repeated again, or there is a period of refusal of the drug for 2-3 weeks. With each repeated intake of the drug, the subsequent recovery is delayed for 7-14 days, depending on the body's reserves, i.e. the more you take a "loan" from your bank (brain) of neurotransmitters, the more you then "return". In this state, the receptors are not able to perceive the substance as it was on the "pure" organism. Accordingly, you do not experience the proper quality of euphoria or stimulation, as the main effects of psycho-stimulants. You get only side effects from intensive stimulation of adrenergic receptors by increasing the dosage. The use of euphoretics and psycho-stimulants with a multiplicity of 2 times a month or more for a long period of time depletes the main mediators of the central nervous system - dopamine, serotonin, nor-adrenaline. Neurotransmitter receptors begin to turn off so as not to "burn out" and reduce neurotoxicity from excess dopamine. All this leads to a shift in emotional status, and as a consequence of depression and poor physical well-being.
MAIN BRAIN MEDIATORS: Psycho-stimulants inhibit the re-uptake of dopamine and nor-epinephrine in neurons. The predominant influence of psycho-stimulants on the serotonin system is its inhibition, associated with blocking the re-uptake. They also reduce the concentration of serotonin and its metabolites in biological fluids. All this leads to a shift in emotional status - to an increase in mood, euphoria and stimulation of mental activity.
The classical structure of intensive mid-static chronic use, after which it will take a significant time to recover, is as follows - 2-3-4 days of use of the substance with an increase in a single dosage and multiplicity of administration, then there is a phase of "relaxation" for about 4 days, then either the use of the drug is repeated again, or there is a period of refusal of the drug for 2-3 weeks. With each repeated intake of the drug, the subsequent recovery is delayed for 7-14 days, depending on the body's reserves, i.e. the more you take a "loan" from your bank (brain) of neurotransmitters, the more you then "return". In this state, the receptors are not able to perceive the substance as it was on the "pure" organism. Accordingly, you do not experience the proper quality of euphoria or stimulation, as the main effects of psycho-stimulants. You get only side effects from intensive stimulation of adrenergic receptors by increasing the dosage. The use of euphoretics and psycho-stimulants with a multiplicity of 2 times a month or more for a long period of time depletes the main mediators of the central nervous system - dopamine, serotonin, nor-adrenaline. Neurotransmitter receptors begin to turn off so as not to "burn out" and reduce neurotoxicity from excess dopamine. All this leads to a shift in emotional status, and as a consequence of depression and poor physical well-being.
- Acetylcholine,
- Nor-epinephrine,
- Dopamine,
- Serotonin,
- Glutamate,
- GABA.
CLINICAL CONSEQUENCES OF CHRONIC USE.
General symptoms:
- mood swings,
- lack of motivation,
- increased fatigue,
- daytime sleepiness and increased sleep duration.
Cognitive disorders:
- memory loss,
- deterioration of attention.
Psychotic disorders:
- slurred speech,
- thinking disorders,
- delirium.
BODY CONTROL CRITERIA S FOR CHRONIC DRUG USE.
DIET COMPLIANCE.
Your gastrointestinal tract should be ready to process the "drug" and not be in a state of inflammation If drugs are taken orally. The best course would be to take a course on the development of personal rational nutrition. Rational nutrition is not just a balanced diet for micro- and macro-nutrients. This is a full-fledged diet that meets all the needs of the body in terms of energy, compiled taking into account age and gender characteristics, the presence of chronic or concomitant diseases, genetic disorders and enzymopathies. The method of periodic fasting is best suited to the body during chronic drug use - insulin emissions and the load on the cytochromes of the liver are reduced.
Sweet, fried, gastronomic uselessness, fast food is best excluded from the ordinary diet. Balance meals with vegetables, lean meat/turkey/chicken. Give preference to carbohydrates with a low glycemic index. The combined use of eupho-stimulants with high-carbohydrate foods can provoke the development of type 2 diabetes and insulin resistance.
ELECTROLYTE AND WATER BALANCE.
Most of the water is contained in the body of infants - up to 86%. Then its level gradually begins to decline, reaching a minimum in the elderly. Water works as a solvent, forms the basis of biological media, is a participant in various biochemical reactions, thermoregulation and performs many other functions. Every second, our body loses a certain amount of water with breathing in the form of vapors. Other ways of eliminating fluid from the body are sweating, the production of enzymes in the gastrointestinal tract. However, the greatest amount of water in a healthy person is excreted from the body by the kidneys. In the process of blood passing through the kidneys, water, mineral and organic substances enter the urine, which are not required by the body due to their harmfulness or redundancy.
The body needs to take water from the outside To compensate for fluid loss, which is aggravated by the use of drugs. Natural replenishment of water occurs due to drinking and eating. Intravenous administration is used for severe dehydration to quickly replenish fluid loss or inability to drink water through the mouth or with intensive detoxification. The fluid in our body is conditionally divided into intracellular and extracellular. Intracellular fluid, as the name suggests, is present inside the cell and is delimited by a semi-permeable membrane from the space surrounding the cell. Outside the cell, fluid is located in the intercellular space and inside the blood and lymphatic vessels. The water balance in the body should be understood not only as the total amount of water, but also its distribution between the listed structures, which directly affects the vital activity of human organs and tissues when using various types of drugs. Try to use pure, clean water with pH higher than 9 for your daily life.
HORMONE SYSTEM STATUS.
Hormones are a specific type of chemicals whose functions are to regulate all most important processes in the human body. The production of hormones is carried out by the endocrine glands, individual organs and some types of cells. Normally, the female hormones estrogen and male hormones androgens balance each other in the right ratio for each sex. Assessment of the current hormonal status of the female and male body is radically different due to the difference in the processes occurring in the body of a woman and a man. It is hormones that form appearance, indirectly affect behavior and the difference between the sexes. It is enough just to look at the tests of some hormones to understand whether they are male or female. Our body is a bio-machine, and no system can be 100% isolated from another, so hormones and the brain are tightly connected.
Several studies have found that dopamine is not just a health hormone. It also helps to increase the level of growth hormone and testosterone. This increase is mainly due to enhanced RNA expression (mRNA). This gives a direct signal to the testes to produce more testosterone. This is probably the reason why an increase in dopamine leads to increased libido. But there is also feedback - intense releases of dopamine can provoke first a rise and then a decrease in testosterone levels, which manifests itself during abstinent syndrome after the use of many euphoric stimulants. Therefore, it is necessary to prevent the presence of hormonal status disorders when using drugs and perform checkup yourself in advance.
BLOOD VITAMIN D LEVEL.
Vitamin D belongs to the group of fat-soluble vitamins. Vitamin D and its metabolites can be divided into the cholecalciferol group (vitamin D3) and the ergocalciferol group (vitamin D2). Of these, vitamin D3 is formed mainly in the skin under the influence of ultraviolet rays of sunlight, and the source of vitamin D2 is food. Native vitamin D, formed in the skin and obtained from food, is biologically inert. To activate and turn into an active form in the body, it undergoes two hydroxylation processes. The first stage of hydroxylation occurs in the liver to form 25-hydroxyvitamin D (25(OH)D), or calcidiol. 25(OH)D in the blood is carried, in combination with a transport protein, can be deposited in adipose tissue. The second stage of hydroxylation occurs mainly in the kidneys with the formation of the active D-hormone, 1,25-dihydroxyvitamin D (1,25(OH)2D). Evidences show that vitamin D may be involved in neurodevelopment and may have a neuroprotective effect on dopaminergic pathways in the adult brain. The fact that vitamin D increases the levels of tyrosine hydroxylase expression implies that vitamin D could modulate dopaminergic processes. Drugs of abuse act through different mechanisms of action and on different locations in the brain reward system; however, all of them share a final action, in which they increase dopamine levels in the reward pathway. Vitamin D-treated animals showed significant attenuated methamphetamine-induced reductions in dopamine and metabolites when compared to control, indicating that vitamin D provides protection for the dopaminergic system against the depleting effects of methamphetamine. In this article, it is speculated that vitamin D would be an effective treatment approach for drug abuse and addiction, if we consider that vitamin D would provide protection for the dopaminergic system against dopamine-depleting effects of drugs, as it did for methamphetamine. This hypothesis can provide a new direction towards a new treatment approach for drug abuse and addiction, as we have no pharmacological treatments at our disposal at the present moment, although several issues need further examination and check-up.
PREPARING BODY FOR TAKING EUPHORIC STIMULANTS:
DIET COMPLIANCE.
Your gastrointestinal tract should be ready to process the "drug" and not be in a state of inflammation If drugs are taken orally. The best course would be to take a course on the development of personal rational nutrition. Rational nutrition is not just a balanced diet for micro- and macro-nutrients. This is a full-fledged diet that meets all the needs of the body in terms of energy, compiled taking into account age and gender characteristics, the presence of chronic or concomitant diseases, genetic disorders and enzymopathies. The method of periodic fasting is best suited to the body during chronic drug use - insulin emissions and the load on the cytochromes of the liver are reduced.
Sweet, fried, gastronomic uselessness, fast food is best excluded from the ordinary diet. Balance meals with vegetables, lean meat/turkey/chicken. Give preference to carbohydrates with a low glycemic index. The combined use of eupho-stimulants with high-carbohydrate foods can provoke the development of type 2 diabetes and insulin resistance.
ELECTROLYTE AND WATER BALANCE.
Most of the water is contained in the body of infants - up to 86%. Then its level gradually begins to decline, reaching a minimum in the elderly. Water works as a solvent, forms the basis of biological media, is a participant in various biochemical reactions, thermoregulation and performs many other functions. Every second, our body loses a certain amount of water with breathing in the form of vapors. Other ways of eliminating fluid from the body are sweating, the production of enzymes in the gastrointestinal tract. However, the greatest amount of water in a healthy person is excreted from the body by the kidneys. In the process of blood passing through the kidneys, water, mineral and organic substances enter the urine, which are not required by the body due to their harmfulness or redundancy.
The body needs to take water from the outside To compensate for fluid loss, which is aggravated by the use of drugs. Natural replenishment of water occurs due to drinking and eating. Intravenous administration is used for severe dehydration to quickly replenish fluid loss or inability to drink water through the mouth or with intensive detoxification. The fluid in our body is conditionally divided into intracellular and extracellular. Intracellular fluid, as the name suggests, is present inside the cell and is delimited by a semi-permeable membrane from the space surrounding the cell. Outside the cell, fluid is located in the intercellular space and inside the blood and lymphatic vessels. The water balance in the body should be understood not only as the total amount of water, but also its distribution between the listed structures, which directly affects the vital activity of human organs and tissues when using various types of drugs. Try to use pure, clean water with pH higher than 9 for your daily life.
HORMONE SYSTEM STATUS.
Hormones are a specific type of chemicals whose functions are to regulate all most important processes in the human body. The production of hormones is carried out by the endocrine glands, individual organs and some types of cells. Normally, the female hormones estrogen and male hormones androgens balance each other in the right ratio for each sex. Assessment of the current hormonal status of the female and male body is radically different due to the difference in the processes occurring in the body of a woman and a man. It is hormones that form appearance, indirectly affect behavior and the difference between the sexes. It is enough just to look at the tests of some hormones to understand whether they are male or female. Our body is a bio-machine, and no system can be 100% isolated from another, so hormones and the brain are tightly connected.
Several studies have found that dopamine is not just a health hormone. It also helps to increase the level of growth hormone and testosterone. This increase is mainly due to enhanced RNA expression (mRNA). This gives a direct signal to the testes to produce more testosterone. This is probably the reason why an increase in dopamine leads to increased libido. But there is also feedback - intense releases of dopamine can provoke first a rise and then a decrease in testosterone levels, which manifests itself during abstinent syndrome after the use of many euphoric stimulants. Therefore, it is necessary to prevent the presence of hormonal status disorders when using drugs and perform checkup yourself in advance.
BLOOD VITAMIN D LEVEL.
Vitamin D belongs to the group of fat-soluble vitamins. Vitamin D and its metabolites can be divided into the cholecalciferol group (vitamin D3) and the ergocalciferol group (vitamin D2). Of these, vitamin D3 is formed mainly in the skin under the influence of ultraviolet rays of sunlight, and the source of vitamin D2 is food. Native vitamin D, formed in the skin and obtained from food, is biologically inert. To activate and turn into an active form in the body, it undergoes two hydroxylation processes. The first stage of hydroxylation occurs in the liver to form 25-hydroxyvitamin D (25(OH)D), or calcidiol. 25(OH)D in the blood is carried, in combination with a transport protein, can be deposited in adipose tissue. The second stage of hydroxylation occurs mainly in the kidneys with the formation of the active D-hormone, 1,25-dihydroxyvitamin D (1,25(OH)2D). Evidences show that vitamin D may be involved in neurodevelopment and may have a neuroprotective effect on dopaminergic pathways in the adult brain. The fact that vitamin D increases the levels of tyrosine hydroxylase expression implies that vitamin D could modulate dopaminergic processes. Drugs of abuse act through different mechanisms of action and on different locations in the brain reward system; however, all of them share a final action, in which they increase dopamine levels in the reward pathway. Vitamin D-treated animals showed significant attenuated methamphetamine-induced reductions in dopamine and metabolites when compared to control, indicating that vitamin D provides protection for the dopaminergic system against the depleting effects of methamphetamine. In this article, it is speculated that vitamin D would be an effective treatment approach for drug abuse and addiction, if we consider that vitamin D would provide protection for the dopaminergic system against dopamine-depleting effects of drugs, as it did for methamphetamine. This hypothesis can provide a new direction towards a new treatment approach for drug abuse and addiction, as we have no pharmacological treatments at our disposal at the present moment, although several issues need further examination and check-up.
PREPARING BODY FOR TAKING EUPHORIC STIMULANTS:
- Hungry pause for at least 3 hours before drug use - reduce the load for the liver and pancreas.
- Eliminate physical and social stressors that may cause a more significant change in the psychological status of the labile psyche under the influence of drugs.
- Drink 1 liter of pH balanced water in portions for an hour of 2 hours before use.
- Omeprazole 40 mg (pharmacy - Zegerid, Gastrogard, Helicide) - 1 hour before the use of euphoric stimulants to reduce the acidity of the gastrointestinal tract
- Acetylsalicylic acid 25-50 mg (pharmacy - Anacin, Ecotrin, Aspergum, Aspirine) 2 hours before drug use. If you have planned a certain day of trip, you can start taking Aspirin at a dosage of 50 mg per day 3 days before the start of drug use.
- Magnesium citrate (look in online stores of dietary supplements) - 1000 mg 2 hours before use, 500 mg during drug-use, 1000 mg after the end of the drug-session.
- Try not to take alcohol together with drugs because it has a very narrow therapeutic corridor and loads many body systems that are busy processing narcotic molecules. Increase in drug toxicity and many side effects occures as a result of euphoric stimulants combined with alcohol.
- Jaw clenching,
- Nystagm,
- Sweating,
- Tingling in the chest,
- Headache.
ADDITIONAL PHARMACEUTICALS IN/AFTER USE:
- L-carnitine (levocarnitine) - 1000 mg an hour before taking euphoric stimulants and 1000 mg after. This protects your brain during the neurotoxic effects of drugs.
- Alphalipoic acid - 250 mg an hour before the drug use and 250 mg after. Enhances the effect of levocarnitine and increases antioxidant activity, and it all help to remove free radicals from the body.
- Vitamin C - 1000 mg once a day trip, and can also be within 3 days after in the same dosage.
- L-tryptophan and L-tyrosine are aminoacids and precursors of serotonin and dopamine. Take once a day L-tyrosine 1000 mg in the morning, L-tryptophan 500-1000 mg in the evening 30 minutes before the expected sleep. Take within a three-week period, the beginning of the course is not earlier than 72 hours after the last use of euphoric stimulants.
- Diazepam (pharmacy - Stesolid, Valium, Nervium, Diazepam Teva) - 10 mg to 30 mg per use if you feel anxiety after using stimulants. Do not exceed the daily dose of 60 mg, and do not reuse psychostimulants after using diazepam.
- Melatonin (Circadin, Regulin, Melagesic RM, PrimeX) - 3 mg for 30 minutes before bedtime. Under proper conditions in the form of lack of light and sound helps to fall asleep faster after use than L-tryptophan.
- Neurotropic vitamins of group B (B1 B6 B12) have a beneficial effect on inflammatory and degenerative diseases of the nerves and musculoskeletal system, so much so if the dietary supplement complex is selected in combination with choline.
- Essential fatty acids help delay the occurrence of early atherosclerosis, and also have a positive effect on the course of any type of depression. It is recommended to take 1 g of omega-3 fatty acids per day with meals.
- Magnesium supplements. Long-term use of stimulants leads to depletion of magnesium reserves in the body. A 50% decrease in magnesium levels can be fatal. Heart attack at the age of 30-40 is most often due to magnesium deficiency. Supplements of choice are magnesium orotate or magnesium citrate. Daily dose of magnesium 330 - 450 mg.
Symptoms of magnesium deficiency:
- Convulsions.
- Extrasystole.
- Arrhythmia.
- Night bruxism.
- Painful sensations in the heart.
- Depression.
- Migraine - activation of migraine status (permanent migraines) is possible.
- Defecation disorders - magnesium plays a key role in the mechanism of intestinal motility.
- Sleep disorders - If you suffer from nightmares and do not get enough sleep at all, then there is a high probability that you suffer from magnesium deficiency.
- Metabolic syndrome - studies have shown that magnesium is able to slow the development of diabetes.
- High blood pressure - magnesium is a natural blocker of calcium channels, so it significantly affects blood pressure.
- Ringing in the ears - many patients restore hearing with drugs that contain magnesium.
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