Comparison between synthetic opioids
- Thread starter Albert A
- Start date
I'll try to answer
1. N-desethyl isotonitazene: It is a derivative of isotonitazene, which acts as an opioid agonist.
Comparison to Fentanyl: In vitro pharmacological data show that N-desethyl isotonitazene is an active opioid agonist and is approximately 20x more potent than fentanyl
2. Etonitazepyne: is a benzimidazole derivative with potent opioid effect.
Comparison to Fentanyl: In data provided by the US Drug Enforcement Administration, etonitazepyne showed much greater agonism to mu-opioid receptors than fentanyl (about 31 times) and morphine (about 42 times). Its agonism to delta-opioid receptors was similar to that of fentanyl and morphine but lower to kappa-opioid receptors. The overall effectiveness of etonitazepine in vivo is 20 times higher than that of fentanyl in humans.
It described euphoria; drowsiness and wakefulness; temporary relief of pain, stress or low mood; itchiness; severe nausea and/or vomiting; severe sweating or fever; slow and/or difficulty in breathing; blue lips or fingertips; cold, clammy skin; tiny pupils; unresponsiveness and/or loss of consciousness. These reports were not verified, and no further details.
3. Protonitazene: is a benzimidazole derivative with potent opioid effects
Comparison to Fentanyl: Scientists calculated the potency (EC50) and efficacy (Emax) of protonitazene relative to those of fentanyl and hydromorphone. Protonitazene was highly active in mu-opioid receptors activation, with a potency and efficacy slightly greater than those of fentanyl (107%) and significantly greater than those of hydromorphone (174%).
Protonitazene was analytically confirmed in nine fatal poisonings or deaths in the USA. Although data on humans are limited, a review of original research on benzimidazole opioids noted that, when administered intravenously, all the drugs caused respiratory depression, with a narrow therapeutic ratio between analgesia and respiratory depression
4. Metonitazene: is an analgesic compound related to etonitazene. It has been shown to have approximately 100 times the potency of morphine by central routes of administration, but if used orally it has been shown to have approximately 10 times the potency of morphine.
Comparison to Fentanyl: Scientists calculated the potency (EC50) and efficacy (Emax), of metonitazene, relative to Fentanyl and Hydromorphone (HM). In mu-opioid receptor activation, metonitazene was highly active, with potency and efficacy slightly greater than fentanyl (113-121%) and significantly greater than hydromorphone (184-340%).
Separately, I would like to note that the pharmacological profiles of all substances make people think that they can be used in the presence of tolerance to achieve the desired effect. However, combintations of fentanyl or classical opioids with these synthetic substances with opioid properties often led to fatal outcomes. Be careful
1. N-desethyl isotonitazene: It is a derivative of isotonitazene, which acts as an opioid agonist.
Comparison to Fentanyl: In vitro pharmacological data show that N-desethyl isotonitazene is an active opioid agonist and is approximately 20x more potent than fentanyl
2. Etonitazepyne: is a benzimidazole derivative with potent opioid effect.
Comparison to Fentanyl: In data provided by the US Drug Enforcement Administration, etonitazepyne showed much greater agonism to mu-opioid receptors than fentanyl (about 31 times) and morphine (about 42 times). Its agonism to delta-opioid receptors was similar to that of fentanyl and morphine but lower to kappa-opioid receptors. The overall effectiveness of etonitazepine in vivo is 20 times higher than that of fentanyl in humans.
It described euphoria; drowsiness and wakefulness; temporary relief of pain, stress or low mood; itchiness; severe nausea and/or vomiting; severe sweating or fever; slow and/or difficulty in breathing; blue lips or fingertips; cold, clammy skin; tiny pupils; unresponsiveness and/or loss of consciousness. These reports were not verified, and no further details.
3. Protonitazene: is a benzimidazole derivative with potent opioid effects
Comparison to Fentanyl: Scientists calculated the potency (EC50) and efficacy (Emax) of protonitazene relative to those of fentanyl and hydromorphone. Protonitazene was highly active in mu-opioid receptors activation, with a potency and efficacy slightly greater than those of fentanyl (107%) and significantly greater than those of hydromorphone (174%).
Protonitazene was analytically confirmed in nine fatal poisonings or deaths in the USA. Although data on humans are limited, a review of original research on benzimidazole opioids noted that, when administered intravenously, all the drugs caused respiratory depression, with a narrow therapeutic ratio between analgesia and respiratory depression
4. Metonitazene: is an analgesic compound related to etonitazene. It has been shown to have approximately 100 times the potency of morphine by central routes of administration, but if used orally it has been shown to have approximately 10 times the potency of morphine.
Comparison to Fentanyl: Scientists calculated the potency (EC50) and efficacy (Emax), of metonitazene, relative to Fentanyl and Hydromorphone (HM). In mu-opioid receptor activation, metonitazene was highly active, with potency and efficacy slightly greater than fentanyl (113-121%) and significantly greater than hydromorphone (184-340%).
Separately, I would like to note that the pharmacological profiles of all substances make people think that they can be used in the presence of tolerance to achieve the desired effect. However, combintations of fentanyl or classical opioids with these synthetic substances with opioid properties often led to fatal outcomes. Be careful
This is not such a simple question. Because there are a lot of application points and hard-to-read variables. Maybe the following table can help you:
| Opioids | POTENCY RELATIVE TO MORPHINE | DURATION OF ACTION (HOURS) |
| Codeine | 1/10 | 3-6 |
| Pethidine | 1/8 | 2-4 |
| Tapentadol | 1/3 | 4-6 |
| Hydrocodone | 2/3 | 4-8 |
| Oxycodone | 1.5-2 | 3-4 |
| Methadone | 5-10 | 8-12 |
| Hydromorphone | 4-7.5 | 4-5 |
| Buprenorphine | 80-100 | 6-8 |
| Fentanyl | 50-150 | 72 |
It's also a pretty interesting table
- By middlemaneu
Table is not correct.. only very few fentalogues are properly studied from medicine, since during the golden age, as soon as a good one was found, other companies just used the same name to sell more products - that's why there are so different opinions between users and various papers. Acetyl-F (15x) and Furanyl-F (25x) are the only one I knew with detailed references / studies on humans. Here car-f being 10'000x is totally a fake, it's 1250x approx. in humans.
i'd give a kidney to have some of those golden age analogues... Zenes class was just a terrible mess, poor recreational value unless recreational means just nodding, fall asleep and passing out - except maybe for Etazene - but tolerance destruction is the shit same for all. At least chinese offered a cure 10 years before medicine...even if debated, more than 40 ppl i now with dinosaur tolerance with Zenes (100-150mg IV!!!) managed to quit Zenes without little to no WD by using SR-17018.
In the last few months finally new classes started to come out, and more will see he light soon. Both low-, middle- and strong potency. IMO the perfect candidate is a 15-20x. easy to dose from low-potency users, strong enough with higer dosage from strong-potency users, and especially, won't be used to cut out of a gram 300g of synthetic heroin sold as heroin or pressed "oxy" pills.
i'd give a kidney to have some of those golden age analogues... Zenes class was just a terrible mess, poor recreational value unless recreational means just nodding, fall asleep and passing out - except maybe for Etazene - but tolerance destruction is the shit same for all. At least chinese offered a cure 10 years before medicine...even if debated, more than 40 ppl i now with dinosaur tolerance with Zenes (100-150mg IV!!!) managed to quit Zenes without little to no WD by using SR-17018.
In the last few months finally new classes started to come out, and more will see he light soon. Both low-, middle- and strong potency. IMO the perfect candidate is a 15-20x. easy to dose from low-potency users, strong enough with higer dosage from strong-potency users, and especially, won't be used to cut out of a gram 300g of synthetic heroin sold as heroin or pressed "oxy" pills.
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- By Paracelsus
Greetings. Do you have any objective data to back up your words? I would be very interested in studying them. There is a lot of new information out there now
- By middlemaneu
Hi there,
do you mean papers about Fentalogues potencies in human? Or Zenes? (lot of new papers public and private released in the last 2 years) - regarding the new classes of strong opoids that have been publicly released (next one occuring very soon), we can have a talk via PMs/ safer comms channels.
do you mean papers about Fentalogues potencies in human? Or Zenes? (lot of new papers public and private released in the last 2 years) - regarding the new classes of strong opoids that have been publicly released (next one occuring very soon), we can have a talk via PMs/ safer comms channels.