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Alcohol and Tramadol
When a person consumes alcohol, it goes to the brain where it affects the function of certain neurotransmitters, including GABA and glutamate. These neurotransmitters play a role in regulating mood, behavior, and other cognitive functions. Alcohol increases the activity of GABA, which can lead to feelings of relaxation and pleasure. It also reduces the activity of glutamate, which can cause impairments in cognitive function, such as memory loss, difficulty thinking clearly, and slowed reaction time.
Tramadol is a prescription pain medication that is used mostly to treat moderate to severe pain. When tramadol is taken orally, it is absorbed into the bloodstream through the digestive tract. From there, it is carried to the brain where it binds to opioid receptors. Tramadol can also inhibit the reuptake of serotonin and norepinephrine, which are neurotransmitters involved in pain perception, among other things. Common side effects of tramadol include dizziness, drowsiness, nausea, and constipation. More severe side effects can include respiratory depression.
The combination of Tramadol and Alcohol can be dangerous because both substances are depressants, which means they slow down the activity of the brain. When taken together, the combination can increase the risk of drowsiness, respiratory depression, coma, and other and other side effects associated with central nervous system depression.
Among the side effects characteristic of the combination of alcohol and Tramadol, one can also highlight:
- Increased intracranial pressure and recurring episodes of headache.
- Frequent nausea, vomiting, and abdominal pain.
- More likely to cause liver damage than when using these substances alone.
- Impaired kidney function up to renal failure
There are cases of severe convulsive seizures when Tramadol is used in combination with one or another substance. In the case of Alcohol, this is most likely due to impaired liver function and the multi-vector activity of Tramadol on neurotransmitters. While Alcohol and Tramadol have different touchpoints, they may be synergistic in lowering the seizure threshold.
Finally, various studies show that the simultaneous use of Alcohol and Tramadol increases the potential for substance abuse and is directly associated with higher mortality.
All things considered, we recommend avoiding this combination.
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