Example of isomer separation for Meth

[btcboss2022]

Hello,

After receive and see many questions about Meth resolution process I decided to show you an example with my own pics(not professional ones as you will see hahaha):

- 3.65L of "dirty" freebase(just separated and dried after hydrolysis process)

- 5.11L of water

- 2.55kg of L-tartaric acid(dextro-tartaric acid, d-tartaric acid)

- Mix the L-tartaric with the water until all dissolved

- Add the freebase to the mixture while vigorous stirring

- After around 2 min stirring the mixture is hot and becomes thick and later a solid mass

Now the process is practically finished just leave it at RT 24 hours and filter it with vacuum.
D-meth freebase will appears after after turning the liquid part alkaline(PH 13).

I hope this help you ;-)

 

[Mo0odi]

Cool
Thank you

 

[btcboss2022]

I forgot to clarify that to avoid long discussions sorry hahaha

L-tartaric acid CAS 87-69-4

 

[花谢花开]

Hello, master, do you need to heat it during this period?

 

[btcboss2022]

I never did it, it's an exothermic process itself. Thanks.

 

[Osmosis Vanderwaal]

I wonder why the conventions, +/- and R/S have not universally applied. It seems ,1R,2R tartaric acid, 1S,2S, tartaric acid and the non- optically active 1R,2S and 1S,2R mesomers is a lot more informative

 

[btcboss2022]

It works with MDMA freebase and Ketamine freebase too just changing ratios with molar weight of each freebase. Remember that in the MDMA and Ketamine case the interesting isomer will be in the solid part using these reagents ;-)

 

[CryoThio]

Pretty sure for mdma shulgin found that both enantiomers are required for the "full" effects.

I don't think separating the enantioners is worth it for mdma

 

[btcboss2022]

As you know each person has his preferences about sensations and feelings and some people like effects of L-MDMA and viceversa I cant have an opinion because I never taste it I always used racemic one but I read in that forum possitive feedbacks about L-MDMA

 

[riahisunak]

Hi,
You said this would work with MDMA and ketamkme , just use molar equivalents .
But your ratios don't match the the molar equivalents
3650÷149.2337=24.5 moles
24.5×150.09= 3670g of L tartaric
150.09mm L tartaric
149.2337mm M
??

 

[FredDurst]

btcboss2022 Do you recycle the L-Meth again the get a higher yield as in this diagram? :

 

[btcboss2022]

No

 

[btcboss2022]

Until I arrived not possible at big scale except with big autoclaves etc and Im not prepared for that I will try an easiest method and will see.

 

[FredDurst]

Got ya. Just wondering if anyone has had success doing this

 

[btcboss2022]

I guess that probably not or at very small scale for testing not in a continuos production way.

 

[Jordan Belfort]

You can apply the same principle in a different way by simple overreacting

 

[hustlerkid]

Can you provide synthesis to convert L meth to D meth?

 

[Jordan Belfort]

Putting freebase back in a new reaction does the same

 

[FredDurst]

Could you explain bit please? You put your L-Meth Freebase into new reaction?

 

[btcboss2022]

I guess he means to add it to a new batch separation.
When you have another racemic batch add the L-meth and make the separation process.

 

[Jordan Belfort]

Throw the l-freebase in a new reaction what is there not to understand and see later after seperating

 

[Jordan Belfort]

Over reacting with ultrasound does exactly the same but depends on the reactants. I use a modified barbier type reaction without thf or any buffering solvent.

Goes from clear to cloudy to dark brown

 

[FredDurst]

Understood

 

[btcboss2022]

Honestly I never used that and I dont know how it works I should study it but does exactly the same separating isomers or turning L-meth racemic ?
Because goes from clear to cloudy dont means anything specific could be for other reasons.

 

[Mr Good Cat]

Is there any detailed description of this process? Is it the same for MDMA?

 

[FredDurst]

This diagram was the only bit of info I have found on this process. It is from a European law enforcement report explaining the different methods mostly found in EU. It didn't go into much detail.

Why would you need to separate isomers of MDMA?

 

[Mr Good Cat]

I love to resolve difficult questions. And it looks MDMA isomers are different from meth.

 

[ZACARIASKLK123]

@btcboss2022​

Man as always, good info.