Express Return Method for Obtain Amphetamine sulphate

[GhostChemist]

Express return method for obtain Amp sulphate​

General scheme of the processes. Scheme 1

Scheme 1​

Starting reagents and materials

• 3 g AMP sulfate
• 50-100 ml IPA
• 20 ml IPA + H2SO4 (concentration unknown)
• 30-60 g NaOH
• 200-250 ml H2O
• Beakers
• Separating funnel 250 ml
• Pipettes
• pH-indicator strips
• Filters
  

The process of A sulfate solubility in solution of H2SO4 in IPA. Scheme 2

Scheme 2​

A sulphate is placed into a beaker Fig 1

Fig 1​

A solution of ~25% sodium hydroxide is prepared (30 g in 100-120 ml H2O) Fig 2

Fig 2​

20-25 ml of IPA is added to the A sulfate. Fig 3

Fig 3​

Sulfuric acid solution in IPA is added dropwise until A sulfate is dissolved (Scheme 2) Fig 4

Fig 4​

The formation of the free base occurs according to Scheme 3

Scheme 3​

An alkali solution is added to the A hydrosulfate solution. Fig 5

Fig 5​

25-50 ml of IPA is added to the resulting mixture. Fig 6

Fig 6​

The mixture is transferred to a separatory funnel and the upper layer of IPA containing free base A is separated. If separation is poor, an additional portion of alkali (25-30% solution) and IPA is added. Fig 7

Fig 7​

The formation of sulfate A again is shown in Scheme 4.

Scheme 4​

A solution of sulfuric acid in IPA is slowly added to the IPA layer with constant stirring, drop by drop, until the mixture reaches a neutral reaction. Fig 8

Fig 8​

The mixture should have a neutral pH. Fig 9

Fig 9
​

The resulting precipitate was filtered off. Fig 10

Fig 10​

The precipitate is dried on the filter Fig 11

Fig 11​

Yield 2.95-3 g Fig 12

Fig 12​

Confirmation of consist A - adding a granule of alkali to the sample and a drop of water - a specific smell of the free base should appear​

The impurity will be an inert and safe salt - sodium sulfate.​

To obtain a purer product, distillation of the free base with steam is used.​