How to reduce phenylacetone with lithium aluminum hydride(LiAlH4)

Aleffine

Don't buy from me
Member
Language
🇺🇸
Joined
Jan 14, 2023
Messages
3
Reaction score
0
Points
1
Hi,
I saw in the forum that p2p was reduced with sodium borohydride and Al/Hg, but these two are not available in my country, except for lithium aluminum hydride. Is the process of reducing p2p with lithium aluminum hydride the same as sodium borohydride?

Thanks
 

w2x3f5

Don't buy from me
Resident
Language
🇬🇧
Joined
Jan 15, 2023
Messages
358
Reaction score
179
Points
43
It would be logical to obtain an imine in anhydrous THF from p2p and methylamine, then drop this solution into a mixture of lithium aluminum hydride in anhydrous THF.
 

Aleffine

Don't buy from me
Member
Language
🇺🇸
Joined
Jan 14, 2023
Messages
3
Reaction score
0
Points
1
Thanks
 

w2x3f5

Don't buy from me
Resident
Language
🇬🇧
Joined
Jan 15, 2023
Messages
358
Reaction score
179
Points
43
Please note that when an imine is formed from p2p and methylamine, water will be released; the water must be bound.
 

btcboss2022

Don't buy from me
Resident
Joined
Mar 15, 2022
Messages
650
Solutions
1
Reaction score
662
Points
93
Deals
8
Why does practically no one talk about the reduction of P2P in THF with ammonia(NH3) and LiAlH4 to obtain amphetamine?
Furthermore, surprisingly, I have found little information about it, but at first glance, it seems short enough and not excessively difficult to warrant some attention. Or am I missing something when analyzing it apart from the water issue?
4 P2P +4 NH3+LiAlh4 → 4 Amphetamine + Al(OH)3 + LiOH
 

w2x3f5

Don't buy from me
Resident
Language
🇬🇧
Joined
Jan 15, 2023
Messages
358
Reaction score
179
Points
43
Sodium borohydride produces a large amount of dirt at the exit. I will assume that the secondary amine reacts more readily with p2p, plus the reduction reaction of p2p. I don’t see any advantages to using lithium aluminum hydride
 
Top