I know there have been a lot of similar questions here, but I will still ask again.. how to synthesize 2-bromo-4-methylpropiophenone😶

[a-WoWoMu]

I know there have been a lot of similar questions here, but I will still ask again.. how to synthesize 2-bromo-4-methylpropiophenone

 

[xoxoxoxo]

u have video how to made it

 

[antrax]

just buy it already made.

 

[Osmosis Vanderwaal]

Starting from scratch I haven't seen a convenient way. Starting from propriophenone it's not to hard. No one's going to make this video and no one is goingvto make a video of how to season a steak

 

[HerrHaber]

The synthesis of the 4-methyl propiophenone is a very classical Friedel-Crafts acylation of toluene with propionyl chloride in presence of a strong Lewis acid such as anhydrous AlCl3 that only has a tiny amount of 2-methyl-propiophenone. Now brominating the product with bromine in acetic acid or similar results in 2-bromo-4’-methyl-propiophenone. It is only inconvenient to isolate and dry the alpha halogenated ketone since they are all super lachrymators and manipulating it around is hell if the place is not propper.