Good Evening Everyone
I've collected the following resources to open discussion on the synthesis of 3-MeO-2'-oxo-PCE aka Methoxetamine or MXE.
I've lifted the following comment from reddit, courtesy of the users there: /
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And in case it ever goes down (in reference to a DEA document on synthesis of MXE):
https://web.archive.org/web/2020102...les/pr/microgram-journals/2012/mj9-1_3-17.pdf
Some more resources here as well:
A Multi-Disciplinary MXE Analysis by Vortech (RIP) has a chapter on the chemistry
UK Gov't Report has some chemistry info: https://assets.publishing.service.g...chment_data/file/119087/methoxetamine2012.pdf
WHO report as well: https://www.who.int/medicines/areas/quality_safety/4_22_review.pdf
And some past threads on it with lots of valuable info on difficult individual subprocesses in the synth:
/r/TheeHive/comments/9yoguq/mxe_total_synthesis/
/r/TheeHive/comments/iposiu/a_total_synthesis_of_mxe_otc/
/r/TheeHive/comments/9x3gh8/another_theoretical_mxe_synthesis/
/r/TheeHive/comments/j90agw/mxe_synthesis_again_new_route/
/r/TheeHive/comments/9w97qg/synthesis_of_methoxetamine_and_other/
/r/researchchemicals/comments/99efk5/feasibility_of_synthesizing_mxe/
/r/TheeHive/comments/9gb5jr/mxe_synthesis/
/r/TheeHive/comments/hhk93s/alternative_synthesis_routes_for_mxe_copied_from/
/r/DrugNerds/comments/104r3f/methoxetamine_synthesis/
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A potential route is presented as follows:
https://pastebin.com/ed9r9VnP
Which is similar to the one posted here:
bbgate.com
I like this method to produce Methoxetamine, but I just wish we can open discussion further! What can be replaced with this and that, how can we alter the formula, etc.
I've collected the following resources to open discussion on the synthesis of 3-MeO-2'-oxo-PCE aka Methoxetamine or MXE.
I've lifted the following comment from reddit, courtesy of the users there: /
---
And in case it ever goes down (in reference to a DEA document on synthesis of MXE):
https://web.archive.org/web/2020102...les/pr/microgram-journals/2012/mj9-1_3-17.pdf
Some more resources here as well:
A Multi-Disciplinary MXE Analysis by Vortech (RIP) has a chapter on the chemistry
UK Gov't Report has some chemistry info: https://assets.publishing.service.g...chment_data/file/119087/methoxetamine2012.pdf
WHO report as well: https://www.who.int/medicines/areas/quality_safety/4_22_review.pdf
And some past threads on it with lots of valuable info on difficult individual subprocesses in the synth:
/r/TheeHive/comments/9yoguq/mxe_total_synthesis/
/r/TheeHive/comments/iposiu/a_total_synthesis_of_mxe_otc/
/r/TheeHive/comments/9x3gh8/another_theoretical_mxe_synthesis/
/r/TheeHive/comments/j90agw/mxe_synthesis_again_new_route/
/r/TheeHive/comments/9w97qg/synthesis_of_methoxetamine_and_other/
/r/researchchemicals/comments/99efk5/feasibility_of_synthesizing_mxe/
/r/TheeHive/comments/9gb5jr/mxe_synthesis/
/r/TheeHive/comments/hhk93s/alternative_synthesis_routes_for_mxe_copied_from/
/r/DrugNerds/comments/104r3f/methoxetamine_synthesis/
---
A potential route is presented as follows:
https://pastebin.com/ed9r9VnP
Which is similar to the one posted here:
Methoxetamine (MXE) synthesis
Introduction Methoxetamine (also known as MXE, 3-MeO-2-Oxo-PCE, 2-(ethylamino)-2-(3-methoxyphenyl)cyclohexan-1-one) is an arylcyclohexylamine and a derivative of eticyclidine (PCE). It can also be thought of as the β-Keto-derivative of 3-methoxyeticyclidine (3-MeO-PCE), or the N-ethyl homologue...
bbgate.com
I like this method to produce Methoxetamine, but I just wish we can open discussion further! What can be replaced with this and that, how can we alter the formula, etc.