Novel tryptamines….

Rabidreject

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Okay so I’m sure some people are aware iv been making,n-DMT and other tryptamines using reductive amination at cold temps…
so I’m wondering, seeing as there are so many things based on the 2,5-dimethoxybenzaldehyde, I’m curious what if you were to use that as the source of aldehyde in this reaction?
i also wondered the same of cyclohexanone but as a ketone of course…

so with the former would you hypothetically obtain something like 2,5-dimethoxy-4-methyltryptamine? Would this be active?

how about n-cyclohexyltryptamine?

are any of these likely to be active at all? I need to try and do more general reading on structure activity relationships, which is my plan over the weekend on a couple subjects, this being one of them….

I guess it just got me thinking….
 

Rabidreject

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Am I being mental? I’m surprised no one has chimed in here….are most chemists here doing am-her and stuff?
 

DavidNichols

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Piperidine derivatives of tryptamines serve no purpose. Loss of potency and no distinctive effects.
You mismatch tryptamine nomenclature and phenethylamine.
 
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