Question Possible new precursor of racemic amphetamine

kitboy

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I found this phenylalaninol reagent a while ago.

Chemical Formula phenylalaninol:
C9H13NO
Chemical Formula amphetamine:
C9H13N

cas:5267-64-1
D-phenylalaninol
cas: 16088-07-6
D L-phenylalaninol
cas:3182-95-4
L-phenylalaninol

The prices are somewhat high but D-phenylalanine is the one with the best price. Could D-amphetamine be made with this product?

Could the Moscow route be used?

Or would it be better to use some kind of hydride?

Could someone help me with this synthesis?

At the current price I don't think it would be profitable to do business with it, but I think it could be worth it for anyone who wants to make batches of D-amphetamine. If I'm right, can someone help me out?



BlSb9vT7Ly


PUM3JfE8a6
 

kitboy

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(+)-D-Phenylalaninol​

CAS: 5267-64-1​



Complexity : 99.7.
Compound Is Canonicalized : Yes.
Covalently-Bonded Unit Count : 1.
Defined Atom Stereocenter Count : 1.
Defined Bond Stereocenter Count : 0.
EC Number: 226-086-1.
Exact Mass : 151.1g/mol.
Formal Charge : 0.
Heavy Atom Count : 11.
Hydrogen Bond Acceptor Count : 2.
Hydrogen Bond Donor Count : 2.
IUPAC Name: (2R)-2-amino-3-phenylpropan-1-ol.
Isotope Atom Count : 0.
Monoisotopic Mass : 151.1g/mol.
Rotatable Bond Count : 3.
Topological Polar Surface Area : 46.2A^2.
UNII: A6QY3U3O3V.
Undefined Atom Stereocenter Count : 0.
Undefined Bond Stereocenter Count : 0.
XLogP3 : 0.7.

prices:
5g
25,00 €

10g
25,00 €

25g
41,00 €

50g
58,00 €

100g
81,00 €

500g
226,00 €

The cheapest price I found. I think you can get a better price by buying from China.
I don't see a bad price if you can do D-amphetamine

@G.Patton @William D. When I have time I might take a look
thanks in advance
 

Precursor-hk

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G.Patton

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There are no any commercially beneficial ways to make amphetamine from this precursor.
 

kitboy

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Even if it's not worth it, couldn't the OH group be reduced?

At least I'll learn something new.

It is assumed that the alcohol could be reduced to alkene and then hydrolyzed?

Sorry if I ask too many questions
 
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