I am interested in conducting a synthesis of Phenylacetoacetonitrile under phase transfer conditions using aliquat 336(15grams per mol of phenylacetonitrile) and 50% sodium hydroxide solution(as water or (methanol 60grams in 200ml)/ polar phase) with toluene as non polar phase, ethyl acetate as electrophile, phenylacetonitrile anion as nucleophile , here is the classic parallel synthesis using sodium; http://www.orgsyn.org/demo.aspx?prep=CV2P0487, here is a summary; https://chemistry.stackexchange.com...ndensation-using-sodium-hydroxide-or-carbonat , a darzen condensation; https://chemistry.mdma.ch/hiveboard/rhodium/pdf/darzen.ethyl.chloroacetate.pdf. In what order would you imagine I should add the reactants; I intend on adding everything all at once as in the classical synthesis?;
, should I use a concentrated sodium hydroxide solution in water or in methanol for the polar phase since in the darzen condensation under ptc conditions there is precedent for the use of a methanol sodium hydroxide solution as reported in the rhodium archive?; https://chemistry.mdma.ch/hiveboard/novel/000333551.html post No 339354.
Does anyone have any expertise or have attempted this I should like to know of your experience before I pull the trigger on this synthesis.
Does anyone have any expertise or have attempted this I should like to know of your experience before I pull the trigger on this synthesis.