Snorting VS Injecting VS Smoke Heroine
- Thread starter DieYoung
- Start date
High bioavailability does not always mean the best. In fact, it all depends on what you mean by "the best". Are you unfamiliar with the substance and want to try it? Have you tried it several times and can't figure out which suits you best? Are you an experienced user and want to overcome tolerance? Etc.
thanks I'm just curious another question does benzo tolerance affect opiate tolerance?
- By Paracelsus
Despite different primary mechanisms, both benzodiazepines and opiates can have overlapping effects on certain brain systems, like the mesolimbic dopamine system, which is involved in reward and addiction. Chronic use of either drug can alter brain chemistry and receptor functioning in ways that might affect the overall sensitivity of the central nervous system to various CNS depressants. In short 
- By Amphetfred24
If I may add something, benzos and heroin are a bad mix.
Even for people with lots of experience.
I OD'd 6 times in my career, each time mixing benzos and heroin.
I smoked for years + needle formany years too. Rarely snorted..
Heroin can be a cruel mistress
Even for people with lots of experience.
I OD'd 6 times in my career, each time mixing benzos and heroin.
I smoked for years + needle formany years too. Rarely snorted..
Heroin can be a cruel mistress
injecting is so dangerous, its much hard to OD while smoking as you feel the effect afther every hit imediatly, snorting and injecting are riski becaues you too 100-200 mg at one line and wait to kick and sometimes heroin can be cut with somethink even deadly, as for injection its the same you inject a full dose and it kick imediatly but if heroin was bad you can die from your normal dose you are feeling safe, so my best ROA is smoking its litteraly if heroin is strong you can fall asleep long before you OD
For some reason I had almost no effect while smoking from foil, tried several times with tolerance breaks with no effect
- By loadingST
Are you on methadone, or probably a heavy injecter ?
This is kind of what happened to me I think. Ever since the fentanyl epidemic, my ceiling for opiate tolerance has been ridiculous. Trying to go back to anything weaker than fentanyl doesn't allow me to get a "high". I used IV when I could but mostly sniffing street bags. Now I use 80mg of methadone syrup orally daily and even the strong stuff doesn't hit like it used to. I've never had much luck with smoking it, always just seemed like a huge waste.
- By Blammo
Theses are all theoretically helpful, seems varying degrees.
The most recent and promising is SR17018. An experimental drug, it seems to be able to help reduce tolerance and I believe offset withdrawals. Double check me on that, but there are some reports on reddit of this being very helpful for people addicted to potent drugs like fentanyl, the zenes, spirochlorphine, ultra potent opioids known to jack up tolerance quickly.
Second is ultra low dose naltrexone, or ULDN. I can't remember how it is supposed to work, but I believe it is helpful in reducing tolerance buildup. Not 100%, just slowing it down. I don't think it inherently reduce tolerance like SR17018, just reduce the build up rate. It was investigated to for distribution in a pill with oxycodone, but for some "odd" reason they didn't finish the trials IIRC. It's super low doses, I forget exactly but like 1 to 20 micrograms, not milligrams, micrograms a day.
NMDA antagonists. They supposedly help reduce the rate of tolerance build up as well. Seems memantine is a good choice, but if you don't have access, then dextromethorphan, the cough syrup ingredient, does the same thing. Consider taking a longer acting syrup like delsym, as that will keep the drug in your system longer.
Together, this can reduce the rate of tolerance build up and with the SR 17018, make it easy to reduce usage and quit.
I've wanted to see what happens if someone used all three from the start, and see how fast tolerance builds up.
The most recent and promising is SR17018. An experimental drug, it seems to be able to help reduce tolerance and I believe offset withdrawals. Double check me on that, but there are some reports on reddit of this being very helpful for people addicted to potent drugs like fentanyl, the zenes, spirochlorphine, ultra potent opioids known to jack up tolerance quickly.
Second is ultra low dose naltrexone, or ULDN. I can't remember how it is supposed to work, but I believe it is helpful in reducing tolerance buildup. Not 100%, just slowing it down. I don't think it inherently reduce tolerance like SR17018, just reduce the build up rate. It was investigated to for distribution in a pill with oxycodone, but for some "odd" reason they didn't finish the trials IIRC. It's super low doses, I forget exactly but like 1 to 20 micrograms, not milligrams, micrograms a day.
NMDA antagonists. They supposedly help reduce the rate of tolerance build up as well. Seems memantine is a good choice, but if you don't have access, then dextromethorphan, the cough syrup ingredient, does the same thing. Consider taking a longer acting syrup like delsym, as that will keep the drug in your system longer.
Together, this can reduce the rate of tolerance build up and with the SR 17018, make it easy to reduce usage and quit.
I've wanted to see what happens if someone used all three from the start, and see how fast tolerance builds up.
That is some very interesting information, I have never heard of any of it. I have actually heard of the naltrexone being useful, but it was not used in the same manner. It was taken in small amounts on a daily basis to alleviate withdrawal symptoms or something, but it was just another "myth" of addict trash talk to me.