Synthesis of P2P by oxidation of alpha-methylstyrene with Oxone (Potassium Peroxomonosulfate) (1kg scale)

[WillD]

Reaction scheme:

Synthesis:
1. 25 liters of acetonitrile and 5 liters of water were added into the 200 L reactor.
2.1000 g a-methylstyrene, 5202 g potassium peroxymonosulfate and 127 g sodium iodide were added to the reactor.
2. The reaction mixture was stirred for 24 h at room temperature.
3. After this time, the reaction mixture was diluted with 85 liters of water and extracted with 30 liters DCM.
4. Water layer discarded, DCM extract was removed to afford a yellow oil.
5. Yield of phenylacetone, about 1000 g.

 

[hardik696]

Sir can you riteup this prosess in smoll scale?

 

[The-Hive]

Just half everything and go from there Trial and error

 

[WillD]

No problem. Do you have reagents? We can make synthesis

 

[hardik696]

Sir not yet but i buy.

 

[hardik696]

https://m.indiamart.com/ get everything here

 

[WillD]

There is a lot of deception on this site, when it comes to specific chemistry. But Oxone - this product is for swimming pools, it is sold in the appropriate stores. AMS and NaI basically available too. Acetonitrile can be replaced in some cases. What country are you in? You can write a PM for more synthesis details.

 

[Jamroz]

Can i change oxone other reagent ? Because is to hard to buy on big scale in my country

 

[WillD]

Potassium peroxymonosulfate or another strong oxidizer

 

[hardik696]

don't have reactor.can I use plastic barrel or metal barrel or Steel. Please reply.PM

 

[Ortist]

Thats insane amount of acetonitrile. Can it be substituted?

 

[Andrzej]

1) What is the role of acetonitrile in this reaction? Only solvent?
2) Why need such big amount of acetonitrile in comparsion to other ingridients?

 

[situ1984]

Hi，What concentration of acetonitrile should I use?

 

[hustlerkid]

Curious what the replacement for acenitrile is for this reaction?

 

[The-Hive]

Ethanol believe it or not

 

[hustlerkid]

It can be replaced 1:1?

 

[jasper]

what is the a-methylstyrene cas? used

 

[The-Hive]

UTFSE or Google it

 

[jasper]

sir can we use a-methylstyrene as liquid form?

 

[The-Hive]

You can buy it £10 1lt

 

[jasper]

yes can we use liquid in place of powder form cause it's written gram

 

[The-Hive]

Weigh the liquid to 1000g