Isomers and tartaric acid

btcboss2022

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I think something wrong with graph.
If you use L+-tartaric acid(cheaper and easier to find)the D enantiomer(amph,Meth) will be in the solution not in the solid as there appears.
If you use D-tartaric acid(more expensive and difficult to find) the D enantiomer(amph,Meth) will be in the solid.
Thanks.
 

G.Patton

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His scheme is correct. Salt is precipitated into the solid state. No difference, d-amphetamine l-tartaric acid salt or l-amphetamine d-tartaric salt. You can change acid and get difference isomer in the solid state with following procedures.

P.S. same for methamphetamine.
 
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Davidrobinson

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What do you mean under pic 18.
"We precipitate d-amphetamine with an additional amount of d-tartaric acid". I thought the d tartaric acid you used crashed the l amphetamine d tartaric salt out. How is it going to precipitate the d amphetamine left in the solution?
 

UWe9o12jkied91d

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D-tartric leaves the desired enantiomer in solution, your solid is now your waste in this case, opposite for L-tartaric (the common one), you then precipitate with your desired acid. During both these processes you will arrive at the sulphate or phosphate, as the tartrates are not storeable
 

Davidrobinson

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I understand that. But if you read the procedure that is posted , here it is.
"Extract with 5 ml of petroleum ether and warm the solution, add 2.45 g of d-tartaric acid in alcohol solution to the mixture. Then add alcohol until completely dissolved and cool with stirring. The l-amphetamine d-tartaric salt precipitates. The d-amphetamine remains in the solution. You can repeat procedure of cleaning precipitate of l-amphetamine d-tartaric salt by methanol to increase yield."
This next bit i am talking about .
"We precipitate d-amphetamine with an additional amount of d-tartaric acid. We filter the precipitate, get the base of d-amphetamine, adding alkali to pH = 11"
 

G.Patton

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I mean that excess of d-tartaric acid precipitate d-amphetamine as well. It is sort of a/b extraction. I think you can skip this step and acidify ether solution after first d-tartaric acid addition.
 

Davidrobinson

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Ok. But how can you precipitate d amphetamine with d tartaric acid, When you seperated
l amphetamine d tartate with this same tartraic acid in the step before
 

Davidrobinson

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There is alot of confusion around this topic. Hopefully your video sheds some light on it .
 

G.Patton

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I did it in equimolar ratio. For d-amph d-tartrane excess is used.
 

smallworker

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It sounds good this way

I have another way. I used L++ tartaric. I make the base oil and l++ tartaric together.
I make 1.4L h2o and put 700gr tartaric together. This mixture i put on 1L freebase oil.

After few minutes he became solid. I let cooldown the mass and will after few hours separated by centrifuge
We oil who comes out i make to ph11/12 to receive the base oil
And the powder how stays in the centrifuge i makr this with hot water and also bring with naoh to ph 11/12 to take the base oil

D and L seperated..


Some suggestion to make it better?
 

UWe9o12jkied91d

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Are you seaprating the watery layer from solvent layer before centrifuge? It sounds to me like your're wasting product in the water layer if yes, but maybe I don;t understand.
 
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smallworker

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Yes i take off from the solid piece all water into filterpaper an than put together the water and the water from the centrifuged solidnmass.

This together i make with noah ph 12
 

UWe9o12jkied91d

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yes, probably, he's describing the L-tartaric route. he centrifuges to remove as much solvent and l-amph as possible then basifies his solid product( d-amph l-tartrate) and reprecipitates as far as I understand, which is good
 

G.Patton

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Hello. Your d-amphetamine L-tartaric salt will not precipitate in water because it is soluble in water. As I wrote in my manual, you have to use alcohol for tartaric acid.
 
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