Mephedrone (4-MMC) Synthesis [2B4M, Ethyl Acetate, Methylamine HCl]

[siko]

hello
9. Sodium bicarbonate 5% H2O solution 300 ml was poured into flask with freebase then stirred for 30 mins. After that layers are
how much Sodium bicarbonate do you put in the recipe?

 

[ghostimage]

you must not use soda on any step of 4mmc, it is produce more problems than solutions, all you need is wash wash wash.
bromination ccan be done with 100% yields with clean result, amination...yes, only 3-5x waterwash, acidation, again, can be done clean way, but at least one wash is must.

 

[Dr. MMX]

Thank you for interest in the topic, but its the topic about final reaction from the 2b4m,
Synthetise of 2b4m should be discussed under its topic. Dont mess with peoples minds and discuss the following reaction here only.

 

[siko]

hello Dr. MMX do you know where i can buy methytlamine hcl

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[Dr. MMX]

Most often purity of 4 methylopropiophenone is 95%, we should know the exact data but if we cant, we use 95%, so for 1 mole of 4 methylopropiophenone we do use one mole of hbr.

4′-methylpropiophenone (CAS 5337-93-9) 1000 g
. Hydrobromic acid 48% aq . 1155 g or 775 ml. Hydrogen peroxide
(H2O2) 35% 980g, (plus 20-30% excess.
H2O2 will decompose during the reaction)
Sodium bicarbonate (NaHCO3) 595.5g,
Distilled water.
Glacial acetic acid 432ml


1. 1000g of 4'-methylprophiophenone is added to the flask.
2. Hydrobromic acid (HBr) 1155 g or 775 ml 48% is poured into the flask and stirred for 5 min. Temperature set to 60c using a water bath.
3. Hydrogen peroxide 35% 1200g is added to the drip funnel.
4. Glacial acetic acid is added through the cooler, wait until it stops "dripping".
5. H2O2 is added in small amounts. Orange/red bromine is released. When the reaction slows down we add acetic acid in small amount, equal to the total amount to be used of h2o2
6. Repeat the steps until you add 50% h2o2.
7. The temperature of the reaction mixture must be increased to 70-75c, after increasing the temperature, the addition of h2o2 and acetic acid can continue.
9. After adding all the reagents, stir at 70-75c for an hour. 10. As a result of lowering the temperature, 2b4m is formed.

Glacial acetic acid is neutralised with equal amount of nahco3 in water.


For futher reaction 90% of purity is starting data.

 

[siko]

not understand sorry what do you get from this ? 4-mmc or 2b4m

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[ghostimage]

bk4 - 2b4m, i point to this in the end

 

[siko]

hello does anyone know where i can buy it ?

Methylamine HCl​

 

[Dr. MMX]

We do have reagents market, please check it out.

 

[siko]

ok thank you

 

[siko]

hello dr.mmx if i want a yield of 500 g 4-mmc can you please list the quantities i need ?
thank you

Reagents:

1. 2b4m
2. Ethyl Acetate
3. Distilled water
4. NaOH
5. Methylamine HCL
6. Acetone
7. HCL acid

 

[dnBQByvHb8Zkawbjpx]

Consider 50 % yield (it could be more but also less if mistakes are made) so take any recipe that starts with 100 g BK4 and go x10. But to cook it in one batch you'll need to think more about temperature control especially while adding methylamine, stirring that volume etc. Also, acidification in aqueous environment without acetone is something to consider, it saves on reagents and is good for the yield too, but may take longer to obtain finished product depending on your options for drying and crystallization.

 

[Dr. MMX]

reagents x5 of the amount in the post, however for this starting temp should be 30c


but this method should be choiced when there is no other options.

Ethyl acetate do react with methylamine, and by using methylamine hcl we get methylamonium chloride.
In the final we dont really receive 4mmc, but something very close.

However when there is no methylamine aq, and we cant prepare the solution it could work to at least receive something.

 

[siko]

thank you