Mephedrone synthesis (4-MMC) in NMP solvent. Large scale.
We already did a succesfull synthesis of 3cmc. The help was greatly appreciated.
My congratulations, friend! You're the best! After such great success in subjugating substances, could you share with your fans your unique experience of this synthesis? because I've been trying for about a month to get a meager but successful result in 3cmc synthesis, but so far I've only had fiascos. I have already tried 5 different solvents, I personally dried acetone by distillation and with anhydrous magnesium sulfate, but after acidification and daily exposure of the glass 
with the product at
-20⁰C, there was not even a hint of crystallization. Tell me the CAS number of the starting substance at the beginning, please?
with the product at -20⁰C, there was not even a hint of crystallization. Tell me the CAS number of the starting substance at the beginning, please?
What step should I undergo if I still have to react the bromine with the 4-methylpropiophenone. In what quantity for this scale? I also need benzene for that, right?
Is there a substitute that can be used instead of benzene?its highly carcenogenic and volatile.if not is there a viable synth of it large scale.sodium benzonate and sodium hydroxide destillation doesnt seem viable to me for large scale.importing it only option?thanks.
Hello, I have been testing this synthesis and have a few questions about it:
1. when adding methylamine 40% in point 3, do you add it all at once, or in small portions making sure the mixture does not exceed 60 degrees?
2. point 4 mentions cold pure water, can it be cooled with dry ice to these 3-5 degrees C?
3. point 8 mentions ice-cold acetone, can I add a large amount of dry ice to it to cool it to -30 / -50 degrees C?
4. point 9 mentions putting the whole thing in the freezer, what is the purpose of this and is it necessary?
In general, I tested this synthesis, I must admit that it works and is fabulously simple, no less I used acetone at 5-10 degrees C, making the final product blue and impossible to rinse. I think it has to do with the warm acetone, at point 8, making a dimmer or some other form of impurity. Do I understand this correctly?
I would like to ask someone in the subject to answer as to the above 4 questions. Greetings
1. when adding methylamine 40% in point 3, do you add it all at once, or in small portions making sure the mixture does not exceed 60 degrees?
2. point 4 mentions cold pure water, can it be cooled with dry ice to these 3-5 degrees C?
3. point 8 mentions ice-cold acetone, can I add a large amount of dry ice to it to cool it to -30 / -50 degrees C?
4. point 9 mentions putting the whole thing in the freezer, what is the purpose of this and is it necessary?
In general, I tested this synthesis, I must admit that it works and is fabulously simple, no less I used acetone at 5-10 degrees C, making the final product blue and impossible to rinse. I think it has to do with the warm acetone, at point 8, making a dimmer or some other form of impurity. Do I understand this correctly?
I would like to ask someone in the subject to answer as to the above 4 questions. Greetings
Hi.
of course this
yes, but your water will turn to ice
Yes, but you don't need to use so cold acetone. -5-10 *C Is enough
The purpose is crystallization. Low temperature helps to form crystals of mephedrone from solution.
of course this
yes, but your water will turn to ice
Yes, but you don't need to use so cold acetone. -5-10 *C Is enough
The purpose is crystallization. Low temperature helps to form crystals of mephedrone from solution.