Methamphetamine synthesis from 1- Phenyl -2 Propanone (P2P) by reductive amination with Sodium Triacetoxyborohydride (STAB)

[w2x3f5]

Dichloromethane, dichloroethane work great, makes the job a lot easier, getting a stab from NaBH4 also works great. Additional acid can not be used for the stab, the reaction is slower due to the lack of additional acid, but in dichloroethane the reaction is faster than in THF. The yield is presumably above 90 percent, the exact yield will be published later, after a few checks.

 

[4real]

Please can you help to break you procedure step by step? Thanks in advance

 

[ItsMee]

Does this work in the same manner with ammonia or ammonium acetate to form amphetamine?
Need an easy way to go to amphetamine from the ketone. Titanium(IV)isopropoxide is an option, but expensive.

 

[w2x3f5]

this may work, need to check

 

[4real]

Please who knows the kind of meth one get from the reaction? D or L or DL?

 

[Speedfac]

From P2P its always racematic Meth , you have to seperate the isomers with Tartaric acid.