New pmk
Cas 718-08-1
The synthesis of Ethyl 3-oxo-4-phenyl butanoate is as follows: Monoethyl monopotassium malonate (12.9 g, 2.3 equivalents) was mixed with tetrahydrofuran (200 ml) and the mixture was cooled to 5°C. Triethylamine (8.2 g, 2.5 equivalents) and magnesium chloride (8.62 g, 2.8 equivalents) were added and the mixture was stirred at 5 to 20°C for 3 hours. The reaction mixture was cooled to 5°C. Phenacyl chloride (5 g, 32 mmol, 1 equivalent) was added gradually and the mixture was stirred for 63 hours at 5 to 20°C. The mixture was cooled to 5°C and 1 N hydrochloric acid (30 ml) was added. Tetrahydrofuran was evaporated under reduced pressure and extraction was performed with ethyl acetate (50 ml). The organic layer was washed with 1 N hydrochloric acid (30 ml), water (10 ml), saturated aqueous solution of sodium hydrogen carbonate (30 ml) and water (10 ml) in sequence. The solvent was evaporated under reduced pressure to obtain the Ethyl 3-oxo-4-phenyl butanoate as a pale yellow oil (5.82 g, yield: 86%).
But has anyone been working on this
And is there any way on phosphorus or lemon
