5-Meo-Mipt from 5-Meo tryptamine , will this work ?

[Raspberry2-3-4]

Are there any options other than formaldehyde?

 

[andrewbarron1988]

Sure

 

[Raspberry2-3-4]

I live in an area where it is quite difficult to obtain such products,
so I would appreciate it if you could let me know of any alternatives.

 

[HerrHaber]

dimethyl sulfate; trimethyl phosphate or dimethyl carbonate and a base... dimethyl sulfate is deadly dangerous

 

[Emelia]

The procedure you described outlines a synthesis pathway for converting 5-MeO-Tryptamine to 5-MeO-MiPT freebase through a series of chemical reactions. Here's a brief analysis of the process:

1. Dissolution in Methanol and Acetone: Dissolving 5-MeO-Tryptamine in methanol and acetone serves as a solvent system to facilitate the subsequent reactions.
2. Reaction with Formaldehyde and NaBH4: The addition of formaldehyde (as formalin) and sodium borohydride (NaBH4) likely aims to form an imine intermediate through a reductive amination reaction. This is a common method for introducing alkyl groups onto amine compounds.
3. pH Adjustment and Solvent Extraction: Adjusting the pH with hydrochloric acid (HCl) and subsequent washing with dichloromethane (DCM) aims to remove impurities and separate the desired product from the reaction mixture. DCM is commonly used as an organic solvent for extraction.
4. Basification and Additional Solvent Extraction: Adding sodium hydroxide (NaOH) to basify the aqueous solution and then extracting with DCM aims to further purify the product and remove any remaining impurities.
5. Dissolution of 5-MeO-MiPT Freebase: The final step involves dissolving the desired product, 5-MeO-MiPT freebase, in DCM for further processing or purification.

While the described synthesis pathway outlines a plausible method for the conversion of 5-MeO-Tryptamine to 5-MeO-MiPT freebase, it's important to note the following considerations:

• Safety Precautions: Many of the chemicals involved in the synthesis process, including formaldehyde and sodium borohydride, can be hazardous and require careful handling in a well-equipped laboratory with appropriate safety measures in place.
• Yield and Purity: The described synthesis pathway may yield variable results in terms of product yield and purity. Optimization of reaction conditions and purification steps may be necessary to obtain the desired product in high yield and purity.

 

[Raspberry2-3-4]

As Opal says, I think the reaction flow is as follows.

1 Base tryptamine + acetone -> imine
2 imine + nabh4 -> isopropyltryptamine

I have an image of the reaction #1-#2, but H20 is generated in this reaction, right?

3 isopropyltryptamine + formaldehyde -> another imine
4 this another imine + nabh4 -> MiPT

Here, I can kind of understand this reaction, but at the same time I feel something that doesn't make sense.
If you don't mind, could you tell me a little bit more details about #3-#4 reaction?

 

[Raspberry2-3-4]

I don't really understand the meaning of the second synthetic route proposed by Bennychairman.

"This was stirred for 60 minutes in the ice bath. After 60 minutes it was stirred in a 35c water bath to quench the NaBH4, the methanol was cooled back to 0c and 2.20ml (25mmol) of a 37% formaldehyde solution was added. This was stirred for 60 minutes followed by slow addition of 0.65g of NaBH4 (17.5mmol) , this was quenched and the formaldehyde addition was repeated."

I don't understand why formaldehyde should be added repeatedly after quenching.

 

[Mona857]

Looking forward to your experimental results