Methamphetamine synthesis from P2P by NaBH4 reduction. Medium-Scale.

[btcboss2022]

Hello,

After many tests using Methylamine HCL based on this method I will share the best way that I found to obtain Methamphetamine freebase in big scale:

• 966 gr P2P​
• 14 liters Methanol
• 1183 gr Methylamine HCL​
• 638gr NaOH​
• 452 gr Anhydrous Sodium Sulfate​
• 105 gr NaBH4​
• 35 L distilled water​
• 7 Liters DCM​

- Fill the reactor with the 14 L of Methanol
- With stirring dissolve the Methylamine HCL
- Put the reactor temp at 0C(not the mixture temp) and add the NaOH, the temp will increase
- Once the temp come back to 20C add the P2P, the temp will increase stir it during 45min-1 hour
- Add 252gr of anhydrous sodium sulfate
- When the mixture temp arrives to 8C start adding portionwise the NaBH4 not exceeding the 20C
- Once all the NaBH4 has been added let it mixing under 20C during aprox 2 hours until the mixture stops bubbling
- Add the water and continue mixing during 5 min
- Add the DCM and mix it during 10 min
- Stop stirring and let layers get separated
- Keep the bottom layer and discard the upper one( not profitable to extract this aqueous phase)
- Add 200gr of anhydrous sodium sulfate to the saved layer and mix it
- Filter it in Buchner Funnel
- Evaporate the DCM
- Clean and smelly Methamphetamine freebase obtained

;-)

 

[workworkwork]

Can I replace sodium sulfate with magnesium sulfate for the both 2 times it is used?

 

[btcboss2022]

Yes you can replace it.

 

[G.Patton]

Depends on crystallization procedure.

 

[Mr.Blanks00]

hello btc, after you have separated the isomer from the oil, how many grams of yield do you get from the D isomer and the L isomer whether you throw it away or use it too.

 

[btcboss2022]

500gr from L and 300gr from D more or less depend the route to obtain the freebase etc etc

 

[JuanoImano4378]

What's the difference between L and D?

 

[johnny.b]

How much methylamine I must use to this reaction if I have 33 % solution in methanol

 

[diogenes]

I think btcboss also uses freebase because after adding the Methylamine HCl he add NaOH to the solution, so makes essentially freebase from the HCl salt.

 

[btcboss2022]

Yes Methylamine HCL+NaOH=Methylamine freebase in my case Methylamine HCL is cheaper and I get more freebase amount with less investment.

 

[jotoy]

Hi
Im a little confuse. So if i buy methylamine HCL and add it in methanol with sodium hudroxide it will becaome a solution?

 

[hunter12]

Yes you use MgSO4, silica gel, 3A molecular sieves or sodium sulfate to dry

 

[jotoy]

IVe done that but something weird happen after to much solid stay after reaction and its very thick i e try to do around 33% methylamie solution in methanol

 

[Felix34-73]

I want to pulverize methamphetamine oil and smell like cocaine. How can I do this, can I make a ph 6 and put it in the freezer? should be usable like cocaine

 

[Acab1312]

Hello Does the method of BTCboss2022 use the anhydrous sodium sulafate as a desiccant or are additional desiccants used?

 

[btcboss2022]

No, it's separated previously.

 

[btcboss2022]

Separate isomers to later cristallize them together dont have any sense you can do that directly from racemic and less work.
The Pic is from D isomer cristallized.

 

[Davidrobinson]

Yer thats what my first question was asking, is that d isomer on its own.

 

[Mr.Blanks00]

can hcl be replaced with isopropyl chloride.

 

[G.Patton]

no

 

[Charlie3]

Hi guys, if the silica gel is blue in colour. is that okay? or does it have to be transparent?

 

[Hank Schrader]

Chemically speaking, methamphetamine is methamphetamine. No matter what method it is obtained, borohydride or hydrogenation, etc...
But to be honest, NaBH4 methamphetamine is very inferior in terms of time of action and quality.
Perhaps minimal impurities that remain in other production methods and give a specific effect to the product.
In the case of borohydride, the action time is up to 16-18 hours and large dosages of the racemic product.
I think the people who synthesized borohydride methamphetamine would agree with me.
For example, methamphetamine obtained by the leukart method and divided into isomers is effective for almost 2 days.
Received methamphetamine through Sodium borohydride and separated into isomers acts only 16 hours and higher dosage.
The absence of impurities in the base is guaranteed by fractional distillation and division into isomers.
Of course, this sounds very strange, because from a chemical point of view, methamphetamine is methamphetamine, but as practice shows, this is not so.
Using the example of Viagra, I can tell you that fizer is unique in the production of sildenefil, and if you compare it with generics that have a similar amount of active ingredient, you will feel the difference.

 

[mithyl2]

Why is NaBH4 methamphetamine inferior? and is there a way to make it as high quality as other routes of synthesis?

 

[Macondor]

and in the MDMA case? can i dm to you?

 

[chuckmcgill]

hello @btcboss2022 @G.Patton I'm following this substituting mdp2p and calculating for molar ratios and something strange happened, instead of dissolving in DCM the organic layer formed a thick sludge like apple sauce in it, making it hard to drain (the sludge tests dark purple/black on marquie reagant like MDMA). We followed your method exactly except we used anhydrous magnesium sulfate instead of your stated dessicant and we used 30% more dessicant than you to make sure it was totally dry. (final Ph of 11 in the water layer)

Do you have any advice for getting the freebase sludge to dissolve into dcm? We cant add dessicant and filter again because the product will stay on the solids

Thanks again cant tell you how much I appreciate your knowledge!

 

[G.Patton]

Hi, please, write in appropriate topic. I'll answer there.