One-pot Amphetamine Synthesis From P2NP With NaBH4/CuCl2 (1kg scale)

[aa1178251182]

I found that magnetic stirring NaBH4 will precipitate, can't add NaBH4 with magnetic stirring nor freezing solven

 

[MadHatter]

Sorry, what do you mean? When and how does the borohydride precipitate? I use magnetic stirring for my attempts, and it works fine.

 

[aa1178251182]

Excuse me, does the crystallization process need to evaporate the IPA solvent to obtain pure amphetamine oil, then use anhydrous acetone as a solvent and add phosphoric acid to form a salt?

 

[MadHatter]

It's best to boil off most of the IPA under acuum just to make drying of the salt easier later. Just put the system under vacuum, attach a condenser and collect your IPA for the next batch in a separate container.

 

[aa1178251182]

I cooled the solvent to 3 degrees in an ice-water bath, then added NaBH4, magnetically stirred with the rotor, creating a downward vortex. NaBH4 precipitates and precipitates at the bottom under stirring at low temperature, and does not react with water in the solvent at low temperature. Do not add NaBH4 at too low a temperature, this stirring method will not work! When producing copper oxide, the agitation does not move

 

[aa1178251182]

 

[aa1178251182]

I can't buy anhydrous acetone, can I use other solvents as crystallization solvents? What are the alternative solvents?

 

[G.Patton]

You can try to buy it in a hardware store and distillate to anhydrous state.

 

[aa1178251182]

Thanks for your reply, acetone is strictly regulated in my country and is not available at all.

 

[G.Patton]

You can add conc. acid to a cold IPA amphetamine free base solution.

 

[aa1178251182]

I don't evaporate the solvent IPA, I add phosphoric acid directly to the mixture of IPA and amphetamine! Can this be crystallized? Let me try it again myself, practice will bring true knowledge

 

[G.Patton]

Yes. Take into account that acid reacts with IPA, don't exposure acid in IPA too long time.

 

[aa1178251182]

 

[aa1178251182]

This kind of reactor is very suitable for this reaction

 

[AKWA]

Yes. I figured with all the mandarin texts all over but a more specific route, Idek what they're called or the site.

 

[UWe9o12jkied91d]

there's 4 glass manufacturers on aliexpress where you can buy directly or talk to a reputed vendor on alibaba

 

[aa1178251182]

 

[aa1178251182]

Add cooling oil to the outer layer to cool down, or heat oil to heat up

 

[blackburn]

Hi would it be possible to do the synthesis in a barrel with a heating mantle, or is a reflux condenser a must? @G.Patton

best regards

Thanks

 

[G.Patton]

Yes, it is possible. You have to use both of them.

 

[blackburn]

Thanks for fast answer.

when you have to heat the contents to 80c for 30 min with the heating mantle, there may be a slight delay before you reach the desired temperature of the contents (80c) , Will this have a negative effect on the synthesis?

Regards

@G.Patton

 

[WinterDust]

No,