The simplest recipe for crystal Mephedrone

[RWG13]

Its possible to adaptate this method for 3-cmc, via changing 2b4m to 2b3c?

 

[mefistofeles]

for the love of god why in the fuck would you want to make this crap 'cause i know damn well you're not making this for yourself.

stop poisoning people and make a good substance like 4mmc or 3mmc, hell, make even 2mmc but leave these chlorinated cats the fuck alone.

i promise you people will be 1000x more satisfied and will come back for more 4mmc

 

[RWG13]

Chlorinated cathinones is not the same with chlorinated amphetamines. Welbutrin is 3 chlorinated cathinone to, and people eat it in quantities 200-300 mg daily for years.
All speculation about toxicity of 3-cmc based on neurotoxicity of 4-chloramphetamine. But 4-CA cause serotonin neurotoxicity because is a potent serotonin releaser lika MDMA, and mechanism of neurotoxicity is same, but more powerful.
MDMA raise serotonin by 900%
4-CA 1100%
And both of them last for 4-5 hours
3-CMC rise serotonin by 300% for 30-45 minutes.
Any other stupid questions?

 

[mefistofeles]

yes, you speak a bunch of bullshit because i didn't say anything about neurotoxicity, let alone serotonin toxicity.

not sure where you got that from, also didn't say anything about chlorinated amphetamines, weird.

i didn't even say anything about any kind of toxicity, you just jumped straight to conclusions.

wellbutrin has been around for a long time and is well researched, it wouldn't be a medication otherwise.

wellbutrin also isn't cytotoxic, while 3cmc is, straight poison. shit makes holes in your nose (i know thats not what cytotoxicity is about but still), and about that neurotoxicity.

while it isn't proved yet i believe that it has to be true, one night with 3cmc worsens my HPPD by a fuck ton and leaves my vision impaired for more than one week, while 2 day binge on 4mmc which releases more serotonin than MDMA makes my vision worse for 2 days and its less impairing than 3cmc.

also has to be toxic to dopamine because its effects resemble early signs of parkinsons, shaky limbs or tremors, shaky breath, quiet speech, impaired memory, impaired walking and coordination, stiff emotionless face, stooping.. and it lasts for a few days after taking it.

the studies on 3cmc's neurotoxicity haven't been even conducted yet, so this isn't 100% not true. this analogy to chlorinated amphetamines doesnt proove or disproove anything.

i do have a stupid question, will you disproove the fact that 3cmc is CAUSTIC/TOXIC NOT NEUROTOXIC?

learn how to read or don't jump straight to conclusions.

what i meant by "poisoning" is that its extremely harmful and toxic to organs and cells

 

[WalterFan]

Does anyone making a higher yield from this synthesis ?

 

[WalterFan]

You mean followed this post completely could reach such high yield or there’s any trick ? I just still has a little confuse about the NMP, after the methylation, should I acidify it immediately or adding NMP is necessary part ? If it’s necessary, then what it does to the synthesis ? I just curious about it

 

[RWG13]

This recipe can be adapted for methcathinone/ethylcathinone?
Just with replacement of 2b4m with 2b-propiophenone and methylamine with ethylamine in case of ethylcathinone?

 

[WalterFan]

I just make it once, I make methylene solution myself, I used cold distilled water for it, then I add it to 2b4mp with benzene, somehow I already can see the separation of layers, anyone can help me ? Because I wash it with water on next step, eventually the outcome is so little, I’m afraid the product was left in the water layer, instead of the top organic layer

 

[61-50-7]

If it's really methylene and not a typing error then you'll never get product from it; you need to add methylamine to the solution and that's only when the reaction is complete that meph is dissolved into benzene, 2B4M is polar so soluble in water, thats where reaction happens

 

[WalterFan]

Sorry, it is type error, what I have is cas 593-51-1; after read your opinion, can i basically only use water to dissolve cas 1451-82-7, then adding NaOH in water, mixed it together first, then slowly adding MA.HCI into the RM and stir, the whole process should be under 30 Celsius and sealed. After all, I finally added benzene for extraction and acidify the benzene layer. Would it be the same, or you have any advice of this idea ? Because I only had few grams product from the benzene layer last time, I strongly believe most of the unreacted Cas 1451 was still left in the water layer, I desperately don’t know how to fix it yesterday.

 

[WalterFan]

Because I have a condition that I do not have any lab equipment this time, I only have plastic box, bucket, cup and a fridge, so the process of making MA.solution 40% from MA.HCI is very hard for me to accomplish, I hope i can have some professional advice.

 

[61-50-7]

Ethyl acetate is preferrer and you can add MeNH2 quickly (with etoac), here a good topic for thhat https://bbgate.com/en/threads/mephe...hyl-acetate-methylamine-hcl.12336/#post-68474

 

[dnBQByvHb8Zkawbjpx]

I have a bunch of questions that I hope someone can answer for me.

1. Solvent
Benzene is hard to obtain in the EU and after discussing this synthesis I've decided to use DCM instead. The original recipe uses 200 ml of benzene but it seems that when DCM is used, 500 ml is a popular amount for the same amount of 2b4mp. How does the different amount of solvent affect the process? Besides better thermal stability during amination (more solvent = more RM volume = it does not heat up as much as compared to lower volume of RM), does the use of more solvent have any other benefits? And can the 500 ml of DCM be cut down to say a half, i.e. 250 ml? (I am aware of the low boiling point of DCM and the necessity to keep the RM below 40 °C.)

2. Methylamine (MA)
MA hydrochloride (MA.HCl) seems to be a popular alternative to aqueous MA (easier transport, storage, stability). Can you just add a base into the RM together with 2b4mp and solvent, and then add MA.HCl directly into the RM? I am advised to use triethylamine as base, would NaOH work equally well?

3. Acidification
This recipe instructs to create a mix of HCl in acetone and add this mixture into the RM in small portions. In other tutorials acetone is added first and HCl is then added drop-wise. Which way is better and why?

4. Filtration
This being the simplest recipe, vacuum filtration using Schott/Buchner funnel is not available. Can I use coffee filters and gravity filtration instead?

5. Acetone
My acetone is declared >99.6 % pure, water content is not declared by the producer. Is my acetone considered dry for this application?

6. Personal protective equipment
Is a gas mask required, or can one wing this with good ventilation or by working in open air?

7. Waste management
I see three types of waste:

1. the aqueous fraction discarded during free base flushing in step 2. This should be just water with some Bromine in it, is it safe to discard in a residential location?
2. the solvents (DCM and acetone) separated during filtration in step 4 and acetone used for washing. How do you discard it safely and responsibly while avoiding cursory screening by the water treatment company?
3. used indicator paper, used filter paper and similar waste material. I assume this can be wrapped, sealed and discarded with household waste, am I right?

Thank you for any advice you can give. This is going to be my first synthesis so I am trying to think about everything in advance and maybe I am overthinking some things. Please tell me if that is the case as well.

 

[Dr. MMX]

glad to hear your doing your 1st steps into that
i simply recommend my method thats posted in synthesis section. I believe I asked you a question if u wanna go easy one or teaching one. Simply choice ethyl acetate and use it for your synthesis. You can use DCM as well but i dont recomment it as 1st stynthesis. You will need more eqfor DCM. In DCM general ruleis that you cant get over 38c becasue it will boil, simply keep temperature at 36-37c and you will have its reaction on about 3h, sometimes less sometimes more. You will know its end of reaction once temperature will not keep itself (abit)
2. You can use HCL methylamine + NaOh, you can use 40% aq solution, you can do 40% aq solution urself(best method). But to do it urself you need serious exhaust fan and a bnit more serious conditions.
3. always one drop per 1s, you can go faster if you know what ur doing, but for start go that way.
4. You can use gravity filtration you can use even cloth for it, its all ok. Buchner/vacuum just helps and makes it faster.
5. 99.6% is good acetone
6. Mask is absolutely required, maybe someone experienced withvery goodexhaust could decide to not wear mask in small scale. For u its necesarry, gloves as well
7. solid wastes put into one bag and throw it to bin far from home, liquids canbe distilled to recover them, but otherwise just spill it in some soil outside when nobody sees.

 

[dnBQByvHb8Zkawbjpx]

Thank you for the answers! Few more points to clarify, if you don't mind:
3. Is it better to first add all acetone (e.g. 400 ml) and then add HCl 1 drop/s, or first mix 40 ml of HCl in 400 ml of acetone and then add this mixture slowly in small portions?
7. I don't think spilling solvents like EA or acetone is a good idea. Would it be possible to just let them evaporate, boil off or even burn in fire (spray small amounts from a syringe into camp fire)?

 

[Dr. MMX]

Put acetone in then seaprately use hcl

yeah you can get rid of solvents this way as well. I personally didnt perform it

 

[Dr. MMX]

you can distill someof solvent under pressure to get it recovered and reuse it. Dont burn solvents in fire its dangerous and will bring attention for sure.

 

[WalterFan]

May I have a question about the ma.HCI part ? I’ve watched your other post about adding ma.HCI directly into the mixture, and I also try it once recently, I have a problem when I dissolved the 2b4m in solvent, should I followed with NaOH + water and start stirring, then adding MA.HCI immediately with small portions? If I didn’t misunderstand it, the whole mixture would turn dark after adding NaOH water, it’s happening before any MA.HCI followed, because it was what happened during my synthesis, so am I did anything wrong ? Or it is normal ? Best regards

 

[WalterFan]

May I have a question about the ma.HCI part ? I’ve watched your other post about adding ma.HCI directly into the mixture, and I also try it once recently, I have a problem when I dissolved the 2b4m in solvent, should I followed with NaOH + water and start stirring, then adding MA.HCI immediately with small portions? If I didn’t misunderstand it, the whole mixture would turn dark after adding NaOH water, it’s happening before any MA.HCI followed, because it was what happened during my synthesis, so am I did anything wrong ? Or it is normal ? Best regards

 

[61-50-7]

Hi, I never try with ma HCl personnally but water turning black with naoh is not very surprising, try to add rge ma hcl not too slow tho, just avoid overheating. sorry for the late reply, I didn't logged for a while. try reX in ipa if the product gets dirty

 

[Dj.Tizo]

Hi
2i new here
amia2i2b4mp is nowhere to find in my country?
Any suggestions please?

 

[Neozion420]

Hi new to this stuff, my synthesis calls for Methylamine free base 40% in (aqueous solution) where would I obtained this without having to go through the trouble of ordering from a big chemical supplier? Thank you