Isomerización del cannabidiol (CBD) en cannabinoides psicoactivos

kitboy

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GqYXjsEBI7


Estaba cocinando CBD y por error añadí NAoh a la mezcla, creo que se detuvo la isomerización. Se formaron 2 capas, ¿alguien puede decirme qué se formó? ¿Es una buena forma de extraer el extracto de THC?

Estoy usando metanol y HCL
 

G.Patton

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Hola, ¿en qué fase se ha añadido el NaOH?

La respuesta puede darla el análisis por HPLC.
 
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kitboy

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Tras 2 horas de isomerización, se formó un aceite pero tiene un olor desagradable y no sé cómo purificarlo.
 

kitboy

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Al añadir Naoh, las dos fases se separaron y creo que la reacción se detuvo. Intenté lavarlo de muchas maneras pero no consigo eliminar ese mal olor.
 

cvvvxa

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las bases convierten el cbd(el thc no se convierte) en algunos derivados de la quinona. creo que se pueden usar diferentes disolventes para separarlo del thc pero no recuerdo cual, ademas en que literatura se describia tambien porque es verde(supongo) algunos impuritos de plantas tambien se pueden oxidar.
 

kitboy

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¿Qué es mejor el ácido acético o el ácido clorhídrico? Me queda un aceite con un olor asqueroso que hago para limpiarlo o extraer las loas de cbd puro del metanol
 

cvvvxa

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el tolueno a temperatura ambiente y el ácido p-toluenosulfónico pueden utilizarse para obtener delta 9 casi puro y otros disolventes con calor dan como resultado delta 8
 

cvvvxa

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tolueno puede ser difícil de eliminar, pero, 44h(48h dará lugar a un poco más de conversión, pero alrededor del 10% delta8) agitó 10% ptsa y tolueno suficiente para disolverlo, a continuación, workup
 

kitboy

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Al añadir agua saturada en NAOH para contrarrestar el ácido, no consigo eliminarlo todo, y si añado demasiada agua la fase superior se vuelve negra. ¿Cómo puedo hacer la extracción? ¿Cómo elimino el olor a ácido? Intenté limpiarlo con agua destilada pero no funcionó.

Necesito ayuda con esto por favor

¿A que PH debo dejar el THC? ¿Puedo usar butano o tolueno para purificar el THC?
 

WillD

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Los métodos que utilizan ácidos en cantidades catalíticas se han establecido mejor que en este tema. Con pTSA 10% mol en DCM (delta-8) o con HCl 0,05% en etanol (delta-9)
 

Dr. MMX

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¿se puede utilizar un alcohol diferente al aclohol etílico? ¿tal vez ipa en su lugar?
¿puede utilizarse hcl?
 
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Irving Langmuir

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Creo que sí, siempre que los reactivos sean solubles. El HCl puede utilizarse como catalizador ácido.
 

WillD

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El cambio de disolvente y la cantidad de ácido modifican enormemente la composición del resultado
 

kitboy

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I think it is better to use methanol
 

Kvadprime

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I love vape with TGK ... I think I can do:

1. We carry out isomerization in ethanol with acetic acid for 12-24h.
2. After - we evolve all ethanol and acetic acid
3. Pour the resin with a mixture of glycerol and propylene glycol, dissolving gravs completely
4. Pour into a comfortable jar and smoke

The issue of health safety - alcohol and acetic acid should clearly not be synthetic - only food (We make THC from the CBD using trembling and sugar, aahahhaha)

Experienced isomerization specialists - what do you think? Is it worth a try?
 

Kvadprime

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I love vape with TGK ... I think I can do:

1. Start reaction in ethanol with acetic acid for 12-24h.
2. After - we evaporate all the ethanol and acetic acid
3. Pour the resin with a mixture of glycerol and propylene glycol, dissolving gravs completely
4. Pour into a comfortable jar and smoke

The issue of health safety - alcohol and acetic acid should clearly not be synthetic - only food (We make THC from the CBD using trembling and sugar, aahahhaha)

Experienced isomerization specialists - what do you think? Is it worth a try?
 

WillD

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You do not have to evaporate it. You can dilute with water and separate the oil if you use ethanol.
 
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Kvadprime

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Hmmm... Of course!
And question

If I use AcOH in concentration about of 70-80%, It get to start isomerisation?

Now.... I can't get or make 100% acetic acid((
 

WillD

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Then you need 7.5 (70%) - 6.5 (80%) mL of acetic acid soln. per ~100mL of ethanol (approximately).
Excess ethanol is necessary for the reaction to go well.
The resulting solution will take 5-10 g of cbd powder, nothing more.
Heat up to 70*C and boil at least 2 hours.
Dilute with water and collect the resulting oil.
You can write us about your results after.
 

Kvadprime

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Ok! I try to do it, thx!!

But 5g cbd in my town i cant get with good price for first try

I try with 1g cbd in 10ml ethanol with ~1ml AcOH

Thx!!!!!!!
 

WillD

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The reaction time can be a little longer than we wrote before. You need to examine to choose the best time if you do not have the opportunity to make an analyst.
 

Rabidreject

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I have wanted to do this for ages but have been holding off as I don’t have p-tsa, however, if d9 is generally done with a catalytic amount of HCl, that would be MUCH easier.
Is it literally a case of chucking it all in, letting it react for ages at RT (12-24h I think I heard), quenching, extracting?

Seeing as THC is by far the drug I use the most, it would make sense for edibles or whatever. Doubt I would want to vape it though. Never was a huge fan of vaping distillate as it just screws my tolerance.

It looks pretty easy though
 

Kvadprime

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Yes, it looks simple. That's why I want to try it!.. I'll write when I do it, there will be another report
 

WillD

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If you use HCl for conversion, then heating is required.
 
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