The profitability of production is very high. With large scale synthesis, the cost per gram can be $3-4. A fair price varies from region to region, but it's usually around $30 per gram +-.
It is recommended for large scale synthesis to allow the bromine and the 4 Methypropiophenone to react with each other for large scale. Or can this synthesis also be used on a larger scale? since when combining the first thing I mentioned, you have to buy Methylene chloride for that. I see that here in this syntesis that is not used.
At 9:03, the instructions say to add "100mL 5% sodium hydrocorbonate..."
Am I to assume that the "sodium hydrocorbonate" is sodium bicarbonate AKA sodium hydrogencarbonate with the formula NaHCO3?
Also, how would this work if the benzene were replaced with dichloromethane?
At 9:03, the instructions say to add "100mL 5% sodium hydrocorbonate..."
Am I to assume that the "sodium hydrocorbonate" is sodium bicarbonate AKA sodium hydrogencarbonate with the formula NaHCO3?
Also, how would this work if the benzene were replaced with dichloromethane?
Yes, To make a 5% solution. Take one part by weight of powder and add it to 19 parts of water by weight of solvent. For example, dissolve 50 grams of sodium carbonate in 950 grams of water.
Are there options to use an other solvent than benzene?
I know the method using ethyl acetate, but I'm not sure if using this here would imply unwanted side reactions or not.
If There are other solvents possible beside EA of Benzene,
I'm all ears
Are there options to use an other solvent than benzene?
I know the method using ethyl acetate, but I'm not sure if using this here would imply unwanted side reactions or not.
If There are other solvents possible beside EA of Benzene,
I'm all ears
In this particular synthetis, could benzene be replaced by an other solvent which is easier to obtain? If so, which one(s), and does the amount change, instead of 600ml?
Kind regards.
o crap. why didnt i see above post earlier. i guess toulen is toulene, is that a 1 on 1 replacement option? does the same apply for DMSO? (which is way easier to obtain)
The profitability of production is very high. With large scale synthesis, the cost per gram can be $3-4. A fair price varies from region to region, but it's usually around $30 per gram +-.
Hello, can you please tell me if it is possible to synthesize on a scale of one kilogram with the same instructions? How long should the stirring or heating time be? If there is a specific point, I would appreciate it if you could let me know.
My first synthesis of mefedrone was semi sucesfull as i managed to synthesize it but I couldn't isolate it properly but since then I've identified the issue and I've managed to synthesize mefedrone with good,consistent high yields.
Hey guys i need some help with synthesis, would appreciate if you guys help me little bit, I'm a beginner at thie chemical thing but i think i understand 80% of this process for other 20% i need some help from you guy
My first synthesis of mefedrone was semi sucesfull as i managed to synthesize it but I couldn't isolate it properly but since then I've identified the issue and I've managed to synthesize mefedrone with good,consistent high yields.
My first synthesis of mefedrone was semi sucesfull as i managed to synthesize it but I couldn't isolate it properly but since then I've identified the issue and I've managed to synthesize mefedrone with good,consistent high yields.
I personally don't do the bromitation reaction I buy the 2-Bromo-4-Methylpropiophenone directly so I can only talk for the methylamination of the bromo ketone to which I don't apply any heat to as it would result in the 4MMC freebase degrading (reaction temperature should not exceed 60°C)
I personally don't do the bromitation reaction I buy the 2-Bromo-4-Methylpropiophenone directly so I can only talk for the methylamination of the bromo ketone to which I don't apply any heat to as it would result in the 4MMC freebase degrading (reaction temperature should not exceed 60°C)