it's the same process, just buy the 2-bromo-valerophenone precursor and add pyrrolidin instead of methylamine and you have a-pvp. That's why i love sn2 reactions they are just so simple
@Novator@G.Patton Can this be scaled? I like the reagents better than the look of the other mephedrone synths posted. I have a reactor with nice heater/chiller is the problem with scaling the heat generated? What is the target tempurature for this reaction? Thanks
The link under the video goes to a write up of a different synthesis in nmp. Is there a link to a write up about this synth? I dont see it, would it be ok to try this at 10x scale same ratio of everything? Thanks
The link under the video goes to a write up of a different synthesis in nmp. Is there a link to a write up about this synth? I dont see it, would it be ok to try this at 10x scale same ratio of everything? Thanks
The captions sometimes disappear a little bit too quickly for me to read them. It seems like the videos / captions have sped up as time goes on. That being said, I always feel empowered and inspired after watching BB.expert videos, the production values are the absolute top of the genre.
If I replace the raw material with phenyl(2-propyl)ketone (CAS 611-70-1), does it mean that I can directly synthesize methcathinone through this operation?
If I replace the raw material with phenyl(2-propyl)ketone (CAS 611-70-1), does it mean that I can directly synthesize methcathinone through this operation?
Thanks appreciate the help! My problem is I have a 50l reactor and the mixer only works if there is at least 2 liters of liquid, maybe I could just add more Ethyl acetate?
Thanks appreciate the help! My problem is I have a 50l reactor and the mixer only works if there is at least 2 liters of liquid, maybe I could just add more Ethyl acetate?
ok I have 5 liter three neck flasks but I dont have an overhead mixer for them just magnetic mantle and it looks like it would be hard for that to stir this mixture properly getting a small reactor could take a few months but if you think it is isnt easy to do a bit bigger I can wait
Do you mean magnetic mantle with stirrer? It doesn't take a reactor, you can carry it out in simple one neck flask and stir it manually or shake it manually in case you don't have a magnetic stirrer (it is the best option).
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Do you mean magnetic mantle with stirrer? It doesn't take a reactor, you can carry it out in simple one neck flask and stir it manually or shake it manually in case you don't have a magnetic stirrer (it is the best option).
yeah i have mantles with magnetic stirrer I just assumed because the powder product isnt very dissolved and there is a lot of it it might not stir with a stir bar. thanks again for your advice
@G.Patton@Novator how long roughly does amination usually take? What temperature does it normally heat to? I tried this at the scale listed, magnetic stirrer was no problem, the color change was not the same as the video, it slowly changed to green/yellow over two hours with a slight exothermic reaction from 13c to 22c, I added a little heat (50c) to try and cause it to react more, it slowly went to yellow/orange and then orange/brown over 20 hours. I was using homemade 40% aqueous methylamine solution that I made from methylamine hcl and naoh and I slowly adding 3x extra in case the solution was not a real 40%. Thanks
how long roughly does amination usually take? What temperature does it normally heat to? I tried this at the scale listed, magnetic stirrer was no problem, the color change was not the same as the video, it slowly changed to green/yellow over two hours with a slight exothermic reaction from 13c to 22c, I added a little heat (50c) to try and cause it to react more, it slowly went to yellow/orange and then orange/brown over 20 hours. I was using homemade 40% aqueous methylamine solution that I made from methylamine hcl and naoh and I slowly adding 3x extra in case the solution was not a real 40%. Thanks
It takes about 20 min as described in the topic. Are you sure that you've added correct amount of methylamine free base? Have you tried to finish your procedure in accordance with guide? Please, continue in the topic comment section (you can mark me to remind).
It takes about 20 min as described in the topic. Are you sure that you've added correct amount of methylamine free base? Have you tried to finish your procedure in accordance with guide? Please, continue in the topic comment section (you can mark me to remind).
I had to make the methylamine 40% from methylamine HCL. I used a post from this forum however the molar ratios seemed a little low in NaOH (40g MethylAmhcl 17g Naoh) but the poster said they had tried many recipes and found only slow addition of NaOH until Ph 12 produced proper results. When the reaction did not proceed quickly I slowly added more methylamine 40% until I had reached a 3x excess (750ml instead of 250ml).
I am following up on crystallization steps today hopefully they worked. Is there good information on the forum for making 40% Methylamine? The info seems to be asked for a lot because the HCl form is easier to get. Thank you!!
It seems that you take not enough NaOH. 40g Methylamine*HCl is 0.59 mole and 17 g NaOH is 0.425 moles. You have to take about the same or more moles of NaOH, man. What post do you mean? In addition, take into account that MeNH2 is very volatile substance and evaporates quite fast.
I have problem because I don't know how to properly generate Methylamine gas I putted 100 grams of Methylamine in 80g of water and mixed in one beaker Then I putted 200 grams of NaOH in erlenmeyer flask which was connected with silicone tubing to ice cold liebig condenser and then to Jar that...
It seems that you take not enough NaOH. 40g Methylamine*HCl is 0.59 mole and 17 g NaOH is 0.425 moles. You have to take about the same or more moles of NaOH, man. What post do you mean? In addition, take into account that MeNH2 is very volatile substance and evaporates quite fast.
I have problem because I don't know how to properly generate Methylamine gas I putted 100 grams of Methylamine in 80g of water and mixed in one beaker Then I putted 200 grams of NaOH in erlenmeyer flask which was connected with silicone tubing to ice cold liebig condenser and then to Jar that...
@G.Patton@Novator how long roughly does amination usually take? What temperature does it normally heat to? I tried this at the scale listed, magnetic stirrer was no problem, the color change was not the same as the video, it slowly changed to green/yellow over two hours with a slight exothermic reaction from 13c to 22c, I added a little heat (50c) to try and cause it to react more, it slowly went to yellow/orange and then orange/brown over 20 hours. I was using homemade 40% aqueous methylamine solution that I made from methylamine hcl and naoh and I slowly adding 3x extra in case the solution was not a real 40%. Thanks
I have encountered the same problem as you. Using methylamine hydrochloride and sodium hydroxide also requires heating, and the color changes from green to yellow. Did you synthesize iodone by yourself? Did you finally synthesize 4-MMC successfully?
Dear Mr. Patton, I have a curiosity which you have advised me to satisfy. Can you explain which solvents to use and create conditions for the synthesis of Clephedron from 2-brom-3-chloropropiophenon? I understand that this synthesis is similar to the synthesis of Mephedrone, but the precursors of these methcathinones have different states of aggregation and I think that this fact can affect the choice of solvent to some extent. I will be very grateful if you explain this synthesis?
Dear Mr. Patton, I have a curiosity which you have advised me to satisfy. Can you explain which solvents to use and create conditions for the synthesis of Clephedron from 2-brom-3-chloropropiophenon? I understand that this synthesis is similar to the synthesis of Mephedrone, but the precursors of these methcathinones have different states of aggregation and I think that this fact can affect the choice of solvent to some extent. I will be very grateful if you explain this synthesis?
Hello, you need 2-bromo-4'-chloropropiophenone CAS 877-37-2 for synthesis of 4-Chloromethcathinone (Clephedrone). So far as solvent in this synthesis concerned, I can't answer you because Idk for sure. I would try same solvents as for 4-mmc at first. I haven't found exact information about this synthesis.
If I replace the raw material with phenyl(2-propyl)ketone (CAS 611-70-1), does it mean that I can directly synthesize methcathinone through this operation?
Hello, you need 2-bromo-4'-chloropropiophenone CAS 877-37-2 for synthesis of 4-Chloromethcathinone (Clephedrone). So far as solvent in this synthesis concerned, I can't answer you because Idk for sure. I would try same solvents as for 4-mmc at first. I haven't found exact information about this synthesis.
my respect the fact is that I have 3-chloropropiophenone (cas: 34911-51-8) available, which differs from 4-chloropropiophenone only in that it is a liquid, but I want to get exactly 3-cmc. So thank you very much for your response to the previous post. And on this occasion, I have the last 2 questions: 1. What role does NMP play in such syntheses and is it possible to do without it at all? and 2. Did you choose the quantities of reagents (participants in the reaction) based on the coefficients in the equation of this reaction or from the consideration that a cheap component should be taken in excess?
Based on this video, this synthesis uses 0.55mol (125g) BK-4 and 2.9mol (250ml*0.9g/ml*0.4=90g) methylamine. What caused the need for an almost sixfold excess of methylamine? And can this negatively affect the yield of the final product? Or maybe I'm wrong in my calculations?
2. Did you choose the quantities of reagents (participants in the reaction) based on the coefficients in the equation of this reaction or from the consideration that a cheap component should be taken in excess?
quite detailed and clear answer, thank you very much. Armed with this information, I am going to conquer this substance right now.I will return with a shield, or on it.
I know it indicated in text that reactions are provided without a vacuum. I just wanted to confirm if this means that the reaction can be complete at normal atmospheric pressure? And that a sealed reaction vessel isnt required?
Great job I want to know is mephedrone similar to cocaine? Does it have the same effects and does it also cause greenness in the tongue like cocaine? And can it be consumed in powder form without becoming crystal?
Great job I want to know is mephedrone similar to cocaine? Does it have the same effects and does it also cause greenness in the tongue like cocaine? And can it be consumed in powder form without becoming crystal?
Mephedrone is similar in action to cocaine and mdma. With nosal use, the duration of action is 40 minutes, causes strong euphoria with light stimulation. Very strongly stimulates sexual desire.
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Hi guys
I leave in iran
I cant find mephedron here
I want to make it
And my question
Is it hard to find substance for make it?
I mean the first parts of it
idoketone refers to the ideal starting material 2-iodo-4-methylpropiophenone or 2-bromo-4-methylpropiophenone which are both classified as ketones using organic chemistry functional grouping. But it should be said if you do not know what an idoketone is, you probably should not be playing with chemicals. which is also probably the reason more than one person has asked that question on this thread and no one is answering them. it is the question only someone with absolutely no knowledge of chemistry would ask. go take some organic chemistry classes at ur local university or whatever then come back MrCook
Thank you a lot.
I already know the video. I just bought all reagents for the video starting with the Bromoketone.
Later I realized, that the route shown in the video by starting from Iodketon is much more attractive because of a smaller amount of different chemicals. Best greetings
Do you know, why so much NMP is used in one of these reactions?
When I compare the videos, it is possible to do this synthesis without NMP as well.
I have heard, that you get higher yields and better product, in the presens of NMP or DMSO as second solvent.
Is this correct?
When I copy this Iodketone route by using the Bromketone. Thank I don't have the colour-changes.
I stopped Methylamine-reaction after I checked that the Temperature is going down.
It was after 32minutes.
In the end two layers seperated. Just during the process, there was not as strong colours like in this video.
When I copy this Iodketone route by using the Bromketone. Thank I don't have the colour-changes.
I stopped Methylamine-reaction after I checked that the Temperature is going down.
It was after 32minutes.
In the end two layers seperated. Just during the process, there was not as strong colours like in this video.
idoketone refers to the ideal starting material 2-iodo-4-methylpropiophenone or 2-bromo-4-methylpropiophenone which are both classified as ketones using organic chemistry functional grouping. But it should be said if you do not know what an idoketone is, you probably should not be playing with chemicals. which is also probably the reason more than one person has asked that question on this thread and no one is answering them. it is the question only someone with absolutely no knowledge of chemistry would ask. go take some organic chemistry classes at ur local university or whatever then come back MrCook
doesn't the EtOAc decompose near completely during the reaction ? what about adding more at the end and extract the meph' like 3 or more times to increase the yield ? Like for DMT extraction
Only noticed this until now.... on 3:15, stopcock is still in the funnel and when taking it off a bump of acid comes out.
I Made that mistake a couple of times. lol
1. I understand I can use a different halogeno-ketone for this reaction. If I use 2-bromo-4-methylpropiophenone, would ethyl acetate still be an appropriate solvent? Ethyl acetate doesn't particularly enhance the nucleophilicty of methylamine. Would a co-solvent help?
2. Why is this being performed under vacuum? It's not typically necessary for an SN2 reaction. Couldn't a solvent like ethyl acetate evaporate under vacuum? What about the pressure in the vessel? Will methylamine evaporate out of solution?
@G.Patton , My question is probably stupid but how do we, from 4MMC freebase and EtOAc, get the two layers just by adding water ( 2:20 ), Is the freebase a oil and not a solid or does another solvent has been added to dissolve the freebase, I don't get it...
@G.Patton , My question is probably stupid but how do we, from 4MMC freebase and EtOAc, get the two layers just by adding water ( 2:20 ), Is the freebase a oil and not a solid or does another solvent has been added to dissolve the freebase, I don't get it...
- Why not salt the water a little with NaCl (2:20 same step) to force the remaining traces of 4MMC in the water into the top layer of oil? Would the impurities also go into the oil ?
- I saw someone mention the use of higher esters such as propyl acetate or butyl acetate, which would apparently have many advantages such as better resistance to bases (MeNH2 in this case) but are also a little less polar, which could dissolve more freebase and increase yield. Could this be relevant ?
- Why not salt the water a little with NaCl (2:20 same step) to force the remaining traces of 4MMC in the water into the top layer of oil? Would the impurities also go into the oil ?
- I saw someone mention the use of higher esters such as propyl acetate or butyl acetate, which would apparently have many advantages such as better resistance to bases (MeNH2 in this case) but are also a little less polar, which could dissolve more freebase and increase yield. Could this be relevant ?
- A little NaCl can be added to separate the layers more clearly.
- Propyl acetate or butyl acetate can be used, but try to synthesize a small amount first. The reaction may go, but you may not be able to extract the product or it will have an unpleasant odor. If I'm not mistaken, someone has used butyl acetate in synthesis before. The availability of solvents also plays a role, ethyl acetate is very available.
can i replace 2-iodo-4'-methylpropiophenone with 2b4m and what need to change in this method . is it same i mean no need to anything just replace 2-iodo-4'-methylpropiophenone with 2 bromo 4 methylpropiophenone
I'm latr to the party, but obviously yes 2b4mp can be used and 2-i-4mp exactly the same way. Im thinking the b is a little more reactive, so the i needs a little extrantime. Don't quote me on that but you can quote me on using either in ethyl acetate with methylamine
can i replace 2-iodo-4'-methylpropiophenone with 2b4m and what need to change in this method . is it same i mean no need to anything just replace 2-iodo-4'-methylpropiophenone with 2 bromo 4 methylpropiophenone
in this video bro got 65g powder without recrystallized
after recrystallized final crystal product become 10gm
my qustion can i use 65g powder in my pills
i wna make 200 mg pill it mens in 1 gm white powerd can i make 5 pill
it means i can make 65x5 = 325 pills of 200mg
.
im asking becouse after recrystallized that 65 gm final crystal become 10 gm it is not worth it
