1-Phenyl-2-propanone (P2P) Leuckart amination to amphetamine and methamphetamine. Smale scale.

[Botsauto-Dutchland]

134g/m p2p 45g/m forma so i calculated :100
1,34g 0,5g X22
I have 30 g p2p so X 22 and i got
30g p2p forma 11gx 5 i read the reaction ratio was best 1:5 and formic acid as catalyst

and next i use hcl to Hydrolise but i had just 50% yield but i had to much water in the ammonium formate /formamide i had produced.
now i heated the solution format/formamide to 175 so i hope this helps..

So what is the yield of this method ?

 

[Botsauto-Dutchland]

yield is higher make sure the p2p is purified and dried, if you mix the formamide and p2p it should mix no layers. and preparing formamide/formate heat it up to 180 Short and then lower it until 170 until no water/acid distils and the just wait a bit more. when stop heating put a cap on the glasware so its air tight.
this way i had from p2p oil to a- 100ml to around 70ml but after vacuum distilling so i wasted some a in the pump and in the start and end i had 60ml perfectly clear a oil.
i wish i could write how much powder i could get 10ml a to aphosfate and to sulfate.

if perfectly pure 10ml 9.4g d/l Amphetamine base is mixed with acid(sulfuric98) what should the powder has in weight, and what should be the excact weight in acid to reach ph?
now with not self made oil it is 1ml acid on 10 grams A oil 10 grams powder. reaction is smoking more when no alcohol used for mixing.
should it be cleaner without ether-acid base wash and perform a steam distil from a stainless steal container steamed true a cooler. ( if the oil contains no p2p) what impurity comes with it.

 

[sponsor]

are you still active here sir ?

 

[Botsauto-Dutchland]

yes i am sorry i mist all this i had some troubles,
it is not alloud in my country what i discussed here.
and the mercury levels costs me 16.000 so i was producing big scale (joke)

 

[Hank Schrader]

I also want to please you, a leukart can be made in a matter of minutes, it is enough to purchase a special chemical microwave and irradiate the mixture of formamide ketone and catalyst in stages.
The yield of formyl derivative is more than 95%.
This is a very good and repeatedly studied technology.

In the right hands, this knowledge will give you a great way out.
If you do the hydrolysis correctly, you will get a yield of over 90%!!!
In the hands of a person who knows what he is doing from 1 kg of unsubstituted ketone, 810-830 ML of the free base of the amine, purified by vacuum fractional distillation, is obtained. After neutralization (6.5-7 pH) and filtering on a centrifuge, we obtain a product that is filled with anhydrous acetone and mixed into a homogeneous mass and filtered again on a centrifuge. Getting 1020 - 1045g of snow-white amphetamine sulfate without a single smell of amine.

 

[OrgUnikum]

Realworld working modified microwaves exist!

 

[Hank Schrader]

I will share the table with you.

 

[OrgUnikum]

Maybe it is just fair to add that temperatures over 180 °C like the named 200 and 210 °C for sure completely destroy P2P and even the Formamide, the resulting vapors and gases are highly toxic. Vent everything coming from top of the condenser outsides! Seriously!
Keep it below 180, better below 175°C and calibrate the Infrared thermometer to the flask/setting you use or you will never exactly know how hot it is.

Good luck

 

[Throw-off]

With Hydrolysis of the formyl amide in these measurements.
NMF - 130ml
P2P - 100ml
Formic - 84ml
How much naoh solution do you need and how much HCI? Is 35% lab grade sufficient?

 

[Acab1312]

The corresponding paper for isomeric separation

 

[OrgUnikum]

And as a free service from yours truly, the ratios for P2P:

Formamide 50 ml 1,5 mol
formic acid 56 ml 1,5 mol
P2P 66 ml 0,5 mol

 

[TheNut22]

Yes, I have noticed, many times, that I buy many solvents, and I use them to get nothing. And again, and again. But this is so interesting that I never give up!

 

[TheNut22]

You didn't get what I was saying, and I know, because I didn't get it now what I wrote... I was refering to those who are lazy and want to get spoon feed the right molar ratios and all that etc... ... and don't bother to read any books or texts about making compound. That is fustrating to me.

 

[G.Patton]

We already work on different amphetamine synthesis ways and new video will be posted soon.

 

[jokerr]

thank you .
I'm looking forward to the p2p amphetamine training video.
good work.

 

[Hank Schrader]

We love the purity of the product.
I have tried many ways to synthesize dextromethamphetamine.
Leuckart, amalgam, electrolysis method, reactor, boron hydride.
A method for obtaining methamphetamine from synthesized ephedrine was also tested.
Ephedrine was obtained in various ways.
For my consumers, I have found the best product with high activity and crystal purity.
The cost of obtaining 1kg of dextromethamphetamine is only ~220-250 euros

 

[OrgUnikum]

Thats teasing. I would be really interested what the best method is, is it a chiral synthesis or splitting the razemate? A hint maybe?

 

[googie]

Does the ephedrine synthesis perhaps involve α-methylamino-propiophenone hydrochloride & nabh4?

 

[OrgUnikum]

How much N-Iso was needed to have the racemic Meth form those nice crystals?

 

[surreyreal]

Pics look excellent. Would it be alright to ask a few questions?

 

[Botsauto-Dutchland]

yes i have to whats the price of 1 liter (medium quality in your countrys)
and about selling is it my paranoia or is it save enough ...
so your selling 10L a week. they find you a pc/networking whatever geek @ the politie.
Nothing is found @ your home and no traces you send packages.
My pc my ip they keep me inside untill furder research is done and that could take a few months ..?
na just paranoia i gues..
i stopped making ampgetamine i will post result in other topic but now i buy oil 100ml 220 euro, it needs to be purified acid/base isnt enought to avoid that dry fucking mouth i didnt had sinds the first 20 time i used. not to high dosage tolance is high right now 160mg solved in water ph 7

oke sorry for off topic

 

[oneimone]

hi every1. in meth synth we use also formic acid as catalyst? and could somebody wright more about hydrolysis with methanol and KOH? i never know about this way.
thx

 

[G.Patton]

It isn't necessary but it is recommended.

 

[Chery]

Тhe temperature indicated in the Leuckart reaction is it the temperature of the PM or the temperature of the hot plate? On one russian site, on the photo I saw that the reaction proceeds at 140 C on hot plate, I carried out the reaction on formamide and formic acid
at a temperature of PM 140 C ( hot plate 200 C) and it started to formed inside the condenser. What is this?

 

[UWe9o12jkied91d]

Formaldehyde residue, you need colder water in the condenser and you should not heat directly on the hotplate, use a sand bath or something

 

[w2x3f5]

Microwave fast synthesis at 180 degrees, correct formamide/formic acid/ketone mixture is important. Also, proper hydrolysis can give a yield higher than that of the formyl derivative, due to the conversion of impurities into the desired amine.
There is a synthesis option according to the Leuckart-Wallach type, but a copper catalyst is used.

 

[OrgUnikum]

It is actually ammonium formate sublimation and your condesner is probably too cold and that is why this happens. I would say you better prepare formamide beforehand and add formic acid this eliminates the problem of having to remove water from the reaction to be able to get temps high enough.

 

[Chery]

thanks for the answer, what temperature should the external heating source or PM have?

 

[G.Patton]

What do you mean PM? Temperature is always means temperature of a reaction mixture (RM).

 

[Chery]

Yes thanks, that's my mistake