Alpha-PVP synthesis (1-10kg scale). Complete video tutorial.

[WillD]

No. 0,9kg (~1L) of pyrrolidine for 1kg alpha-bromovalrophenone.

 

[FishAndChips]

You mean the porpotion is 1L of Pyrrolidine for 1kg
2-bromovalerophenone but how many Ethyl acetate do l need to make Alpha-PVP?

 

[Osmosis Vanderwaal]

2.64848L per kg based on mole density
Mole of 2-b-v=242 grams
Mole of e acetate= 98ml

 

[Osmosis Vanderwaal]

That related to the 4L to 1.5 kg in the list

 

[madmoney69]

I have problems getting it crystalize. What common solutions is for it why I am having problems with getting crystals?

 

[🍒cherry]

I think you must freeze the liquid for 2 days then u can see some crystal forming same like hmtd crystal synthesis not sure it might help
is more important in freezer crystallization

 

[G.Patton]

You can use equimolar proportion and check pH of the solution.

 

[viking1111]

So if i have for example 80l freebase in EA after washing with water, how many l aceton should i use.

 

[komkom]

and how i can get mdpv instead of a-pvp?

 

[Osmosis Vanderwaal]

I'm sputballing here and I'm not a chemist, but I'm guessing you start with 2-bromo-3,4-methylenedioxy benzene, react it with velaryl chloride to get 3,4-MD-valeraphenone

 

[a.hatam]

What could i replace Valerophenone with?

 

[Cranston]

I think you need Valerophenone for Alpha-PVP and Hexanophenone for Alpha-PHP.
Anybody knows the name of the base chemical for Alpha-PiHP?

 

[Cranston]

It's

Isohexanophenone​

or other name being

4-methylpentanophenone​

 

[Cranston]

Of course, even of more interest is the next chemical in the process:

2-bromo-4-methylpentanophenone​

Any one knows a provider for it?

 

[komkom]

After water added at halogenation stage, i have that...
My questions:

1. What i do wrong?
2. It must be dropped out, or i can "save" expensive valphen (#1009...)?

thnx!

p.s. i'am mixing in hands, because my magnet stirrer can't mix it properly (small quantity of liquids)
but,,,, colors, bleaching and other things, are same as in video....

 

[Cranston]

Why aren't you using directly 2-Bromovalerophenone?
It looks easier to get than Pyrrolidine.

 

[viking1111]

Hello i have little problem, for 25k 2bromovalero i use to crysyalization after pirolidyne and after washing, i use to crystalization 1,5l aceton to 0,38 acid per 1kg bromo, but liquid to crystalization i take 1l and make ph 2 with mixture of aceton and acid, after 10h in freezer nothing happend (it was mixing 4 hours with pirolidyne on temp 55) what i did wrong and how to fix it?

 

[Marvin "Popcorn" Sutton]

I suggest we go to private messages and discuss the details with synthesis.

 

[pandachems]

anyone finally got the best finished apvp product ready now?

 

[viking1111]

What u mean

 

[Batracien]

Hello, if I don't want to make a distillation is it a problem ? or is the distillation of the ethyl acetate just used to recover the solvent ? will it cause a problem with the a-pvp salt solubility ?

 

[grow111]

Can you use other solvent instead of ethyl acetate? Maybe IPA or xylene? Does it change results?

 

[G.Patton]

Yes, benzene. It won't.

 

[komkom]

photo #1 2-bromovalerophenone with ethylacetate (my 2-b-vp is crystallized after halogenation may be it problem? but what i do wrong? maybe HBr is too concentraded? but after EtAc added it dissolved)
...
photo #2 decolorized and spoiled after 4-5 drops added of pyrrolidinen to Rm from Photo #1

Many thnx!