Alpha-PVP synthesis (1-10kg scale). Complete video tutorial.

WillD

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No. 0,9kg (~1L) of pyrrolidine for 1kg alpha-bromovalrophenone.
 

FishAndChips

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You mean the porpotion is 1L of Pyrrolidine for 1kg
2-bromovalerophenone but how many Ethyl acetate do l need to make Alpha-PVP?
 
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Osmosis Vanderwaal

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2.64848L per kg based on mole density🤷😜
Mole of 2-b-v=242 grams
Mole of e acetate= 98ml
 
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madmoney69

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I have problems getting it crystalize. What common solutions is for it why I am having problems with getting crystals?
 

🍒cherry

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I think you must freeze the liquid for 2 days then u can see some crystal forming same like hmtd crystal synthesis not sure it might help
⏳⌚ is more important in freezer crystallization
 

G.Patton

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You can use equimolar proportion and check pH of the solution.
 

viking1111

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So if i have for example 80l freebase in EA after washing with water, how many l aceton should i use.
 

komkom

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and how i can get mdpv instead of a-pvp?
 

Osmosis Vanderwaal

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I'm sputballing here and I'm not a chemist, but I'm guessing you start with 2-bromo-3,4-methylenedioxy benzene, react it with velaryl chloride to get 3,4-MD-valeraphenone
 

a.hatam

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What could i replace Valerophenone with?
 

Cranston

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I think you need Valerophenone for Alpha-PVP and Hexanophenone for Alpha-PHP.
Anybody knows the name of the base chemical for Alpha-PiHP?
 

Cranston

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It's
Isohexanophenone​
or other name being
4-methylpentanophenone​
 

Cranston

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Of course, even of more interest is the next chemical in the process:
2-bromo-4-methylpentanophenone​
Any one knows a provider for it?
 

komkom

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After water added at halogenation stage, i have that...
My questions:

1. What i do wrong?
2. It must be dropped out, or i can "save" expensive valphen (#1009...)?

thnx!

p.s. i'am mixing in hands, because my magnet stirrer can't mix it properly (small quantity of liquids)
but,,,, colors, bleaching and other things, are same as in video....
 

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Cranston

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Why aren't you using directly 2-Bromovalerophenone?
It looks easier to get than Pyrrolidine.
 

viking1111

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Hello i have little problem, for 25k 2bromovalero i use to crysyalization after pirolidyne and after washing, i use to crystalization 1,5l aceton to 0,38 acid per 1kg bromo, but liquid to crystalization i take 1l and make ph 2 with mixture of aceton and acid, after 10h in freezer nothing happend (it was mixing 4 hours with pirolidyne on temp 55) what i did wrong and how to fix it?
 

pandachems

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anyone finally got the best finished apvp product ready now?
 

Batracien

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Hello, if I don't want to make a distillation is it a problem ? or is the distillation of the ethyl acetate just used to recover the solvent ? will it cause a problem with the a-pvp salt solubility ?
 

grow111

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Can you use other solvent instead of ethyl acetate? Maybe IPA or xylene? Does it change results?
 

komkom

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photo #1 2-bromovalerophenone with ethylacetate (my 2-b-vp is crystallized after halogenation may be it problem? but what i do wrong? maybe HBr is too concentraded? but after EtAc added it dissolved)
...
photo #2 decolorized and spoiled after 4-5 drops added of pyrrolidinen to Rm from Photo #1

Many thnx!
 

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