7.2.4 Synthesis of Amphetamine hydrochloride
N-Formylamphetamine (1.31g, 8.03 mmol) and concentrated 10M HCl (10mL) were
combined and heated to 130° C for 2 hr.
The reaction was cooled, poured into water (200mL).
This solution was basified with sodium carbonate and extracted into toluene (3 x 50mL),
then dried over anhydrous sodium sulfate.
HCl gas was generated
(NaCl and concentrated sulfuric acid) was bubbled through the solution until a precipitate was
observed,
the solvent was evaporated to afford 2-amino-1-phenylpropane hydrochloride
as a brown solid (0.6 g)
which was recrystallised from acetone to give a white solid
m.p. 145-147° C
(lit? 146-147° C). HPLC analysis indicated the purity of the
hydrochloride salt to be 82%,
the yield of this reaction was (0.49 g, 37%).
'H NMR (200 MHz) 8: 1.4 (d, 3H, CHs), 3.05 (m, 2H, CH2), 3.55 (m, 1H, CH),
7.3 (m, 5H, ArH).
Gas chromatograph retention time: 4.30 minutes.
Mass Spectrum (EI) m/z: 135 (0.005%, M”"), 44 (100%), 91 (36%), 65 (27%), 42
(18%), 51 (11%).
Infrared spectrum Vmax / cm’! Aromatic C-H 3000, N-H 3450.